Hi. I started Zoloft 25mg & my doc will be increasing it to 50mg this week. I started taking it 3 weeks ago. The initial terrible sleep, worse restless legs & increased anxiety is subsiding a bit; it was a starting dose because I cannot tolerate Wellbutrin, Prozac and Effexor didn’t help depression at all! I lost weight on Effexor but haven’t taken anything in almost 2 years. I’m already 30 lbs. heavier than I should be. I do not eat more when I’m depressed... anything positive would be helpful if someone out there has not gained weight... ;/. The reviews are terrible for weight gain on this drug.