strange effects
Acetaminophen/Oxycodone - problems with Rhodes manufqcturing rp 10/325?
Question posted by steele_dollahite on 17 Feb 2016
Last updated on 19 March 2025 (6 weeks ago) by Porterwater123
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18 Answers
Yes, there is a difference, they DO NOT WORK!!! I’ve been in pain mgmt since 2017, Spinal Stenosis/DDD/Bulging disk & more, I’ve notice a drastic change in my pain medication 10/325mg Acetaminophen/Oxycodone, I’ve been researching and discovered they are putting filters and binders in the medication, so you are really getting Tylenol, which does nothing for the pain, I’m suffering with severe sciatica for months now, and been telling my doctor the pain meds are not working.
I agree that Rhodes Pharma has changed their chemistry, made it impossible to get pain relief.
It's thine to put the AMA, CDC and all the manufactures on notice. What they are doing is showing the population that they don't care and it's "OK" to get a Lawyer and file Class Actions Lawsuits.
Action is needed. They want everyone to go to the streets to find pain relief... Their's money in the Fentanyl business, and they are driving the pain suffers that way.
I dont know what compounds have changed in the medication, but I do not receive relief as I should. The country has been put through various medication reformulations and research studies using the general population as subjects. Pain treatment in this country is practically nonexistent or just enough to keep you alive in a miserable state. The mental health agenda has taken the country and world by lunatics in charge. Generic medications are not up to the standards set by the government. How are these companies getting away with it? I could swear all I'm taking is Tylenol with this med. My physician ordered a liver test due to the blood work levels.
Adding during a UA and in high-impact pain, my physician stated you have none of the drugs in your system. NO KIDDING ITS ONLY TYLENOL. FDA should be looking into this along with the DOJ, but the agenda of this current administration is to push new replacements for the drug, making money for all investors! Its seems to be all generic medication for pain control are substandard.
Changing to Rhodes brand caused my mother, who is 81yo to be so dizzy she couldn't stand up! Went on here to see if anything was documented and see it is not uncommon!
I am so glad to see I am NOT the only one with this problem. These Rhodes pills are NOT effective. There is definitely something wrong with them. CVS is constantly trying to push them on me and I always have my doctor write in the prescription that the pills must be from Mallinkrt Pharm. But CVS always tells me that the Rhodes product is the only one they can secure. I suffer because they can't get it right.
I get 10/325 every once in a while to get through really bad pain times as my whole spine seems to just be falling apart. I always felt some kind of relief from previous 10 325 prescriptions until today, when CVS gave me Rhodes RP 10 325's. I immediately noticed they're small round tablets and not the oblong big ones I've always received but thought "who cares" what they look like as they should be the same since I got them from CVS. So far, after taking these tablets, as prescribed, one at a time every 6 hours for a day, and... Nothing. They aren't doing anything.
Rhodes Morphine and Percocet are junk and provide no pain relief. PA, w/o notice, suddenly lowered dose my MD just increased, when I stated Rhodes is useless with numerous complaints. I can't function and asking my original dose reinstated. No pharmacies stocks the best med, Malinckrodt, as inferior Rhodes is cheaper. FDA must inspect this lab, as we chronic pain patients are severely suffering!
Oh good. I'm not the only one. I recently picked up the Rhodes brand, a day ago and so far, nothing. No relief or anything compared to what I've always received from my CVS prescriptions with previous and obviously different brands. I've never even looked at the brands for Percocet's, I just took as prescribed until I got this Rhodes brand. These RP 10 325 's aren't relieving any pain at all.
Not only did they not help after 8 days I started to have withdrawal symptoms which was my final breaking point. I had to actually pay for the pharmacy to replace my medication. Fortunately I have wonderful children and they got the money together. I need a pharmacy I can trust. I am in Palm Coast Florida does anyone have any ideas where to go?
Please file a complaint. I even called Rhodes who did call me back and took a full complaint. I also called my insurance and of course the pharmacy and filled out and sent an online FDA complaint form.
I am a chronic pain sufferer who won't go into details But I have been on pain medication for 21 years.
always did well with Oxycodone 10/325. Just had my prescription refilled at Walmart. the pills looked different and smaller. There now using RP brand. I took 1 and started feeling very sick. went to bed trying not to throw up. I am shakey and dizzy and just feel awful and felt no pain relief.
this medication is not good. What I used to get. Don't know the manufacturer had no side effects whatsoever. I just feel sick from just 1 pill. Can't get anything done on this brand of Oxycodone
I suffer from chronic pain and have been on oxycodone for many yrs. without problems recently had filled a r/x for 10/325 at CVS have had nothing but problems headaches and 0 pain relief manufactured by RHODES
i also have experienced bad case of blurred vision i will not use.
Me too. For years I got occasional relief when my spine is acting up, and then occasionally prescribed Percocet. Picked up the Rhodes brand for the first time recently and they aren't relieving my pain, and it's as if I took nothing. Luckily I don't take Percocet every day so I can get through it, but I feel for a severe/chronic pain user who picks up the Rhodes brand.
I have major chronic pain after a C-spine injury. I have noticed as well issues with the Rhodes manufacture. However I have also noticed that pharmacy are only carrying this manufacture. I had to file a complaint with the FDA, in hopes to get to the bottom of the problem with their medications. I get no pain relief either as well as instant migraine and nausea. If you expenrience issues there is a website you can go onto and file a report. the more of us that file reports the sooner they will investigate them. https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program This should help you get to the site.
Thank you for posting the website to lodge a complaint. I hope others will followup. Rhodes is the only brand stocked, period. Special orders for different generics are no longer permitted.
Keep posting your info about Rhodes. My pharmacist called me last month and informed me that their pharmacy only had 100 (of the 120 oxycodone pills in my script). He then informed me that their pharmacy had pills from either Rhodes or another brand. I told him I wanted to use the other brand and not Rhodes because I learned about Rhodes from this thread. Also there was another bad brand of Oxycodone pills called Cairico. Due to all the complaints, Cairoco got put out of business back in 2019. Maybe the same thing will happen to Rhodes.
This medication does absolutely nothing. How can they get away with this? I took triple the dose and still nothing. Fortunately no stomach issue like others reported. Nothing at all. Like I didn't take anything at all.
Yes! I’ve been suffering from chronic pain and degenerative disc disease among other pain causing illnesses for more that 15 years. I have been prescribed Percocet 10/325 for many of those years, always received the generic version and didn’t experience any side effects. More recently, CVS has started to dispense Rhodes generic and that’s when I noticed a decrease in efficacy ( no pain relief!) and some unwanted side effects. Some are associated with GI issues ( stomach pain, diarrhea etc.) and I see from previous comments, where these could be caused by lactose in the list of excipients in the Rhodes generic and related intolerance. However, I also started sweating profusely after taking each pill and noticed accelerated heart beat.
I have lowered my dose since to 5/325 but the sweating and palpitations didn’t decrease. I can only deduct that these side effects are caused by Rhodes generic Percocet. The generic equivalent I have received at the hospital and /or ER doesn’t affect me and yet relieves the pain.
I find it worrisome that many patients( me included) have “unusual “ side effects while on Rhodes Percocet; if it is indeed a cheaper generic and used by one of the largest retail pharmacies for financial reasons, then this might be a larger issue to be looked into. Chronic pain patients are owed some answers. Life with pain can be complicated enough without having to worry about the efficacy and (safety??? ) of a generic drug like Rhodes Percocet!!!
I have had 4 operations for chronic back pain and have been using various manufactures of 10 mg Oxycodone for more than 15 years. My experience with Rhodes Pharmaceuticals Oxycodone 10-325 was as if I had taken a foul-tasting placebo. I received absolutely no pain relief and suffered opioid withdrawal symptoms after taking maximum dosage. I am now doomed to suffer withdrawal and remain in acute pain for a full month. There appears to be no solution for this dilemma and dozens of similar complaints about Rhodes-manufactured Oxycodone appear throughout the Internet. Would that I had done a google search before accepting this product from CVS. Someone should file a class action suit and FDA should pull Rhodes pills off the market. Rhodes and Pharmacies that sell this cheap, worthless, product should be ashamed and boycotted.
So I have to share my 2 cents about Rhodes. I’ve been using this generic for almost a decade. It works very well for me and has never made me sick. Even with the very first time I took it when switched. The other names listed (I can’t remember them, sorry), I have read so very many negative comments about them, and for the same things... making people sick and not having any pain relief. I think it depends on what you take first: what your body comes to expect from the oxycodone. It’s the fillers that are different. So if you’re started on Rhodes, you get used to it quickly and it works well for you. If your pharmacy changes generics and you’re given a new one, then I can totally understand getting sick from it. With the fillers being different, your body is now having to process it completely differently. So people react to it, and with continued use would get used to it and then it would work. I think this is why there is so much difference in people’s opinions of each brand.
I am a male in my 60s … have had to take generic versions of this drug for 2 decades off and on. Around Oct of last year (2018) I got a regular refill, when I got home I noticed it was not the usual brand … but I took it, it didn't seem to work, gave me an odd feeling and it gave me > well lets just say I had to live in the bathroom on the toilet. I stopped taking it … the problem went away. Started it up again … same problem. I threw it away. Next month same thing happen … if I took Rhodes I got almost uncontrollable trips to the toilet … stop the drug they went away …. had to inform my pharmacy that I could not take this version.
I found out many pharmacies started stocking this brand because of low price cost.
As I said, because of a injury and muscle condition I have take this off and on for 25 years > and never had this issue until I was given 10mg/325mg manufactured by Rhodes
Look up the ANDA #. That brand may have Lactose in it. KVK-Tek does that to many because of the Lactose.
KVK Tech and Mallinckrodt are great! I've never been sick on pain meds until RHODES! IT IS PURE GARBAGE and dozens agree. We all can't be wrong! You call and they say youre screwed, like the no compassion pharmacy. No refunds/returns, you must fight for another script, then get an insurance override to replace this life threatening poison, putting many in the ER. I literally feel like Im dying; first vomiting and migraines. Now severe abdominal, chest and kidney pain to where I can barely walk. Suffering 2 weeks now. I cant see my MD to replace this garbage; and worse it doesn't relieve any pain whatsoever, even in higher doses. Pharms: PLEASE, WE'RE SUFFERING, our insurance and we pay good $$$! Spend a little more for a quality brand! Our lives depend on it! REMOVE THIS POISON NOW! Im making a FDA complaint!
Your experience sounds almost identical to mine. I am so sorry. Please look at my post that has the link to the FDA to file a complaint.
Related topics
pain, acetaminophen, acetaminophen/oxycodone, oxycodone, chronic pain
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- Acetaminophen / Oxycodone uses and warnings
- Oxycodone uses and warnings
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