Zaleplon Side Effects

Some side effects of zaleplon may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to zaleplon: oral capsule

Along with its needed effects, zaleplon may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking zaleplon:

Less common
  • Anxiety
  • blurred or double vision
  • not feeling like oneself
  • Nosebleed
  • seeing, hearing, smelling, or feeling things that are not there

Get emergency help immediately if any of the following symptoms of overdose occur while taking zaleplon:

Symptoms of overdose
  • Confusion
  • clumsiness or unsteadiness, severe
  • dizziness or fainting
  • drowsiness, severe
  • weak muscle tone
  • troubled breathing
  • unusual dullness or feeling sluggish

Some side effects of zaleplon may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Dizziness
  • headache
  • muscle pain
  • nausea
Less common
  • Abdominal pain
  • burning, prickling, or tingling sensation
  • constipation
  • cough
  • difficulty concentrating
  • drowsiness
  • dryness of mouth
  • excess muscle tone
  • eye pain
  • fever
  • heartburn, indigestion, or acid stomach
  • itching
  • itching or burning eyes
  • joint stiffness and/or pain
  • memory loss
  • menstrual pain
  • mental depression
  • nervousness
  • sensitive hearing
  • severe headache
  • shortness of breath
  • skin rash
  • tightness in chest
  • trembling or shaking
  • troubled breathing
  • unusual weakness or tiredness
  • wheezing

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Abdominal and muscle cramps
  • convulsions (seizures)
  • increased sweating
  • sadness
  • trembling or shaking
  • vomiting

For Healthcare Professionals

Applies to zaleplon: oral capsule


General side effects including headache (28% to 38%), asthenia (5% to 8%), fever (2%), malaise (less than 1% to 2%), and photosensitivity (less than 1% to 1%) have been reported.

Nervous system

Nervous system side effects including dizziness (7% to 8%), somnolence (5%), amnesia (2% to 4%), anxiety (less than 1% to 3%), paresthesia (3%), depersonalization (less than 1% to 2%), tremor (2%), hypesthesia (less than 1% to 2%), hallucinations (less than 1% to 1%), and vertigo (less than 1% to 1%) have been reported.


Gastrointestinal side effects including nausea (7% to 8%), dyspepsia (4% to 7%), abdominal pain (5% to 6%), anorexia (<1% to 2%), and colitis (1%) have been reported.


Musculoskeletal side effects including myalgia (5% to 7%) have been reported.


Ocular side effects including eye pain (4%) and abnormal vision (<1 to 2%) have been reported.


Genitourinary side effects including dysmenorrhea (2% to 4%) have been reported.


Other side effects including hyperacusis (2%), parosmia (<1% to 2%), and ear pain (<1% to 1%) have been reported.


Respiratory side effects including epistaxis (<1% to 1%) have been reported.


Metabolic side effects including peripheral edema (<1% to 1%) have been reported.


Postmarketing reports: Nightmares

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