This dosage information may not include all the information needed to use Zaleplon safely and effectively. See additional information for Zaleplon.
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Usual Adult Dose for:
Usual Geriatric Dose for:
Additional dosage information:
Usual Adult Dose for Insomnia
5 to 20 mg orally immediately before bedtime or after the patient has gone to bed and has experienced difficulty falling asleep.
Doses above 20 mg have not been adequately evaluated and are not recommended.
Usual Geriatric Dose for Insomnia
Elderly patients and debilitated patients appear to be more sensitive to the effects of hypnotics, and respond to 5 mg of zaleplon. Doses over 10 mg are not recommended.
Renal Dose Adjustments
No dose adjustment is necessary in patients with mild to moderate renal impairment. Zaleplon has not been adequately studied in patients with severe renal impairment.
Liver Dose Adjustments
Patients with mild to moderate hepatic impairment should be treated with zaleplon 5 mg because clearance is reduced in this population. Zaleplon is not recommended for use in patients with severe hepatic impairment.
Zaleplon should be administered with caution to patients exhibiting signs or symptoms of depression. Suicidal tendencies may be present in such patients and protective measures may be required. Intentional overdosage is more common in this group of patients; therefore, the least amount of drug that is feasible should be prescribed for the patient at any one time.
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Data not available
Taking zaleplon with or immediately after a heavy, high-fat meal results in slower absorption and would be expected to reduce the effect of zaleplon on sleep latency.