Urex Side Effects

Please note - some side effects for Urex may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects by Body System

General

Methenamine is generally well tolerated. Minor side effects have been reported in less than 3.5% of patients.

Dermatologic

Dermatologic side effects have included rash and pruritus.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, diarrhea, anorexia, and abdominal cramping.

Genitourinary

Genitourinary side effects have included dysuria, hematuria, and urinary frequency. High doses have been associated with albuminuria, gross hematuria, bladder wall irritation, and painful/frequent micturition.

Hepatic

Methenamine is contraindicated in patients with severe liver disease due to the risk of systemic acidosis.

Hepatic side effects have rarely included transient elevations of AST (SGOT) and ALT (SGPT).

Hypersensitivity

Hypersensitivity reactions have included rashes in 1% to 4% of patients.

Respiratory

Respiratory system side effects may occur in patients with a poor gag reflex or a swallow disorder. Methenamine oral suspension has a vegetable base, and should be used with caution in elderly patients and in those with swallow disorders to prevent lipid pneumonia. Long-term therapy with methenamine suspension has been associated with lipoid pneumonitis in elderly patients.

Ocular

Ocular side effects have included rare cases of anterior uveitis.

Renal

Renal side effects have been more likely and more severe in patients with mild to moderate renal insufficiency. Methenamine is contraindicated in patients with severe renal insufficiency.

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