Urex Side Effects
Please note - some side effects for Urex may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).
Side Effects by Body System
General
Methenamine is generally well tolerated. Minor side effects have been reported in less than 3.5% of patients.
Dermatologic
Dermatologic side effects have included rash and pruritus.
Gastrointestinal
Gastrointestinal side effects have included nausea, vomiting, diarrhea, anorexia, and abdominal cramping.
Genitourinary
Genitourinary side effects have included dysuria, hematuria, and urinary frequency. High doses have been associated with albuminuria, gross hematuria, bladder wall irritation, and painful/frequent micturition.
Hepatic
Methenamine is contraindicated in patients with severe liver disease due to the risk of systemic acidosis.
Hepatic side effects have rarely included transient elevations of AST (SGOT) and ALT (SGPT).
Hypersensitivity
Hypersensitivity reactions have included rashes in 1% to 4% of patients.
Respiratory
Respiratory system side effects may occur in patients with a poor gag reflex or a swallow disorder. Methenamine oral suspension has a vegetable base, and should be used with caution in elderly patients and in those with swallow disorders to prevent lipid pneumonia. Long-term therapy with methenamine suspension has been associated with lipoid pneumonitis in elderly patients.
Ocular
Ocular side effects have included rare cases of anterior uveitis.
Renal
Renal side effects have been more likely and more severe in patients with mild to moderate renal insufficiency. Methenamine is contraindicated in patients with severe renal insufficiency.
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