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Methenamine Mandelate use while Breastfeeding

Drugs containing Methenamine Mandelate: Uribel, Hiprex, Urelle, Cystex, Hyophen, Uta, Urin D/S, Urimax, Mandelamine, Phosphasal, Show all 46 »Urised, Urex, Urogesic Blue, Uretron DS, Ustell, UTICAP, Prosed DS, Uretron, Uroqid-Acid No2, Trac Tabs 2x, Usept, Darcalma, Utira-C, Utrona, UriSym, Darpaz, Uro-Phosphate, Visqid AA, Prosed EC, Utac, Phosenamine, Uro Blue, UR N-C, Uritin, Utrona-C, Uritact-EC, Urisedamine, Urimar-T, Atrosept, Dolsed, MHP-A, Uritact DS, MSP-Blu, Urapine, Cystemms-V, Utira

Methenamine Mandelate Levels and Effects while Breastfeeding

Summary of Use during Lactation

Both methenamine and mandelic acid pass into milk in small quantities. Methenamine mandelate appears acceptable to use, even while nursing a newborn.

Drug Levels

Maternal Levels. Six mothers nursing newborn infants were given methenamine hippurate 1 gram orally. Five hours after the dose, a mean methenamine concentration of 7 mg/L was found in milk. In two other women, milk concentrations averaged 9.1 mg/L 2 to 3 hours after a 1 gram dose of methenamine hippurate orally and 4.3 mg/L 6 to 7 hours after the dose. Based on the amount of milk ingested, the authors calculated the dose the infants received to be 0.05 to 0.1 mg/kg which is about 1% of the adult dose.[1]

Six mothers were given mandelic acid 3 grams orally 4 times daily, a dose far in excess of that contained in a typical dose of methenamine mandelate. The authors estimated that their exclusively breastfed infants received an average 273 mg of mandelic acid daily in breastmilk. This amounted to an average dose of 86 mg/kg/day in the 6 infants which is about 48% of the adult dosage.[2]

Infant Levels. Six mothers were given mandelic acid 3 grams orally 4 times daily. Mandelic acid was measurable in their breastfed infants' urine.[2]

Effects in Breastfed Infants

Four newborn infants were allowed to breastfeed in one study after a maternal dose of 1 gram of methenamine hippurate. No adverse effects were reported.[1]

Six infants were allowed to nurse during maternal ingestion of the large dose of 12 grams daily of mandelic acid. There was no clinical or laboratory evidence of harm to the infants.[2]

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Methenamine Hippurate

References

1. Allgen LG, Holmberg G, Persson B et al. Biological fate of methenamine in man. Acta Obstet Gynecol Scand. 1979;58:287-93. PMID: 484222

2. Berger H. Excretion of mandelic acid in breast milk. Am J Dis Child. 1941;61:256-61.

Methenamine Mandelate Identification

Substance Name

Methenamine Mandelate

CAS Registry Number

587-23-5

Drug Class

  • Antiinfective Agents, Urinary
  • Antibacterial Agents

Administrative Information

LactMed Record Number

174

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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