methenamine (Oral route)

Pronunciation

meth-EN-a-meen

Commonly used brand name(s)

In the U.S.

  • Hiprex
  • Mandelamine
  • Urex

In Canada

  • Urasal

Available Dosage Forms:

  • Tablet
  • Suspension
  • Tablet, Enteric Coated

Therapeutic Class: Antiseptic

Uses For methenamine

Methenamine belongs to the family of medicines called anti-infectives. It is used to help prevent and treat infections of the urinary tract. Methenamine is available only with your doctor's prescription.

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Before Using methenamine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For methenamine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to methenamine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no special information comparing use of methenamine in children with use in other age groups, methenamine is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of methenamine in the elderly with use in other age groups.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking methenamine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using methenamine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Acetazolamide
  • Mafenide
  • Silver Sulfadiazine
  • Sulfabenzamide
  • Sulfacetamide
  • Sulfacytine
  • Sulfadiazine
  • Sulfamerazine
  • Sulfamethazine
  • Sulfamethoxazole
  • Sulfanilamide
  • Sulfapyridine
  • Sulfasalazine
  • Sulfathiazole
  • Sulfisoxazole
  • Zonisamide

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of methenamine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Dehydration (severe) or
  • Kidney disease (severe)—Patients with severe kidney disease who take methenamine may have an increase in side effects that affect the kidneys
  • Liver disease (severe)—Patients with severe liver disease who take methenamine may have an increase in symptoms of their liver disease

Proper Use of methenamine

Before you start taking methenamine, check your urine with phenaphthazine paper or another test to see if it is acid. Your urine must be acidic (pH 5.5 or below) for methenamine to work properly. If you have any questions about this, check with your health care professional.

The following changes in your diet may help make your urine more acid; however, check with your doctor first if you are on a special diet (for example, for diabetes). Avoid most fruits (especially citrus fruits and juices), milk and other dairy products, and other foods that make the urine less acid. Also, avoid antacids unless otherwise directed by your doctor. Eating more protein and foods such as cranberries (especially cranberry juice with vitamin C added), plums, or prunes may also help. If your urine is still not acid enough, check with your doctor.

If methenamine causes nausea or upset stomach, it may be taken after meals and at bedtime.

For patients taking the dry granule form of methenamine :

  • Dissolve the contents of each packet in 2 to 4 ounces of cold water immediately before taking. Stir well. Be sure to drink all the liquid to get the full dose of medicine.

For patients taking the oral liquid form of methenamine :

  • Use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

For patients taking the enteric-coated tablet form of methenamine:

  • Swallow tablets whole. Do not break, crush, or take if chipped.

To help clear up your infection completely, keep taking methenamine for the full time of treatment, even if you begin to feel better after a few days. Do not miss any doses.

Dosing

The dose of methenamine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of methenamine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For the treatment of urinary tract infections:
    • For oral dosage form (methenamine hippurate tablets):
      • Adults and children 12 years of age and over—1 gram two times a day. Take in the morning and the evening.
      • Children up to 6 years of age—Use and dose must be determined by your doctor.
      • Children 6 to 12 years of age—500 milligrams (mg) to 1 gram two times a day. Take in the morning and the evening.
    • For oral dosage form (methenamine mandelate enteric-coated tablets, regular tablets, solution, and suspension):
      • Adults and children 12 years of age and over—1 gram four times a day. Take after meals and at bedtime.
      • Children up to 6 years of age—Dose is based on body weight. The usual dose is 18.3 mg per kilogram (kg) (8.3 mg per pound) of body weight four times a day. Take after meals and at bedtime.
      • Children 6 to 12 years of age—500 mg four times a day. Take after meals and at bedtime.

Missed Dose

If you miss a dose of methenamine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using methenamine

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

methenamine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common
  • Skin rash
Rare
  • Blood in urine
  • lower back pain
  • pain or burning while urinating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Nausea and vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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