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Perindopril Side Effects

It is possible that some side effects of perindopril may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to perindopril: oral tablet

As well as its needed effects, perindopril may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking perindopril, check with your doctor immediately:

More common
  • Body aches or pain
  • chills
  • cough
  • difficulty breathing
  • ear congestion
  • fever
  • headache
  • loss of voice
  • nasal congestion
  • runny nose
  • sneezing
  • sore throat
  • unusual tiredness or weakness
Less common
  • Abdominal or stomach pain
  • bladder pain
  • bloody or cloudy urine
  • change in hearing
  • chest pain
  • cold or flu-like symptoms
  • congestion
  • difficult, burning, or painful urination
  • dryness of the throat
  • earache or pain in the ear
  • ear drainage
  • frequent urge to urinate
  • hoarseness
  • lower back or side pain
  • swelling
  • tender, swollen glands in the neck
  • trouble with swallowing
  • voice changes
  • vomiting
  • Blurred vision
  • confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • rapid breathing
  • seizures
  • sunken eyes
  • sweating
  • thirst
  • trembling
  • weakness and heaviness of the legs

Some perindopril side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Back pain
  • lack or loss of strength
  • pain or tenderness around the eyes and cheekbones
  • tightness of the chest
Less common
  • Belching
  • bloated
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • diarrhea
  • difficulty moving
  • discouragement
  • excess air or gas in the stomach or intestines
  • feeling sad or empty
  • full feeling
  • hearing loss
  • injury
  • irritability
  • lack of appetite
  • leg pain
  • loss of interest or pleasure
  • muscle aching, stiffness, tension, or tightness
  • nausea
  • neck pain
  • nervousness
  • pain, swelling, or redness in the joints
  • passing gas
  • rash
  • sleepiness or unusual drowsiness
  • stomach discomfort or upset
  • swollen joints
  • trouble concentrating
  • trouble sleeping

For Healthcare Professionals

Applies to perindopril: oral tablet


The most common adverse events were cough, dizziness, and back pain.[Ref]


Very common (10% or more): Cough (up to 12%)
Common (1% to 10%): Dyspnea, epistaxis
Uncommon (0.1% to 1%): Bronchospasm
Very rare (less than 0.01%): Eosinophilic pneumonia, rhinitis[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, paresthesia, vertigo, tinnitus, dysgeusia, drowsiness
Uncommon (0.1% to 1%): Somnolence, syncope
Very rare (less than 0.01%): Stroke[Ref]


Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, nausea, vomiting
Uncommon (0.1% to 1%): Dry mouth
Very rare (less than 0.01%): Pancreatitis
Postmarketing reports: Acute pancreatitis[Ref]


Common (1% to 10%): Hypotension, palpitations, vasculitis, flushing, impaired peripheral circulation
Uncommon (0.1% to 1%): Tachycardia
Rare (0.01% to 0.1%): Sudden cardiac arrest
Very rare (less than 0.01%): Angina pectoris, arrhythmia, myocardial infarction[Ref]


Common (1% to 10%): Pruritus, rash
Uncommon (0.1% to 1%): Urticaria, angioedema, photosensitivity reactions, pemphigoid, hyperhidrosis, eczema, sweating
Very rare (less than 0.01%): Erythema multiforme
Postmarketing reports: Bullous pemphigoid, pemphigus, psoriasis, exfoliative dermatitis[Ref]


Common (1% to 10%): Asthenia, discomfort on exertion
Uncommon (0.1% to 1%): Chest pain, malaise, edema peripheral, pyrexia, fall, atypical chest pain
Postmarketing reports: Serositis[Ref]


Common (1% to 10%): Muscle cramps, back pain
Uncommon (0.1% to 1%): Arthralgia, myalgia[Ref]


Common (1% to 10%): ALT increased
Uncommon (0.1% to 1%): AST increased
Rare (0.01% to 0.1%): Blood bilirubin increased, hepatic enzyme increased
Very rare (less than 0.01%): Hepatitis
Postmarketing reports: Hepatic failure, jaundice[Ref]


Common (1% to 10%): Visual disturbances[Ref]


Uncommon (0.1% to 1%): Renal insufficiency, blood urea increased, blood creatinine increased
Very rare (less than 0.01%): Acute renal failure
Postmarketing reports: Nephritis[Ref]


Uncommon (0.1% to 1%): Hypoglycemia, hyperkalemia, hyponatremia
Postmarketing reports: Symptomatic hyponatremia[Ref]


Uncommon (0.1% to 1%): Eosinophilia, leukopenia/neutropenia
Very rare (less than 0.01%): Agranulocytosis or pancytopenia, hemoglobin decreased and hematocrit decreased, hemolytic anemia in patients with a congenital deficiency of glucose-6-phosphate dehydrogenase, thrombocytopenia, unexplained change in prothrombin ratio
Postmarketing reports: Anemia, leukocytosis, elevated erythrocyte sedimentation rate[Ref]


Uncommon (0.1% to 1%): Mood disturbances, sleep disorder
Very rare (less than 0.01%): Confusion, depression, hallucinations[Ref]


Uncommon (0.1% to 1%): Erectile dysfunction[Ref]


Postmarketing reports: Positive antinuclear antibody[Ref]


1. "Product Information. Aceon (perindopril)." Solvay Pharmaceuticals Inc, Marietta, GA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

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