Perindopril Pregnancy and Breast Feeding Warnings
Perindopril is also known as: Aceon
Overview
Perindopril has been shown to cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Perindopril during pregnancy. It is unknown if Perindopril is excreted in breast milk. Do not breast-feed while taking Perindopril .
Perindopril Pregnancy Warnings
Perindopril has been assigned to pregnancy category D by the FDA. Animal and human data have revealed evidence of embryolethality and teratogenicity associated with angiotensin converting enzyme (ACE) inhibitors. There are no controlled data in human pregnancy. Congenital malformations have been reported with the use of ACE inhibitors during the first trimester of pregnancy, while fetal and neonatal toxicity, death, and congenital anomalies have been reported with the use of ACE inhibitors during the second and third trimesters of pregnancy. If the patient becomes pregnant, perindopril should be discontinued as soon as possible. Perindopril is considered contraindicated during pregnancy.
Drugs that act directly on the renin-angiotensin system can cause fetal and neonatal morbidity and death when administered during pregnancy. A committee of the National Institutes of Health has recommended that these drugs be avoided during pregnancy. The use of drugs that act directly on the renin-angiotensin system during the second and third trimesters of pregnancy have been associated with fetal and neonatal injury, including hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death. Oligohydramnios has also been reported, presumably resulting from decreased fetal renal function; oligohydramnios in this setting has been associated with decreased fetal limb contractures, craniofacial deformation, and hypoplastic lung development. Exposure to ACE inhibitors during the first trimester of pregnancy has been associated with prematurity, intrauterine growth retardation, patent ductus arteriosus, other structural cardiac malformations, and neurological malformations. Mothers whose embryos and fetuses are exposed to an ACE inhibitor should be informed of the risks. When pregnancy is detected or expected, perindopril should be discontinued as soon as possible.
Perindopril Lactation Warnings
There are no data on the excretion of perindopril into human milk. The manufacturer recommends that caution be used when perindopril is given to nursing mothers.
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