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Keflin Side Effects

Generic Name: cephalothin

Note: This document contains side effect information about cephalothin. Some of the dosage forms listed on this page may not apply to the brand name Keflin.

Some side effects of Keflin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Applies to cephalothin: injectable powder for injection, intravenous solution

Hypersensitivity

Hypersensitivity reactions occur in up to 15% of patients with a history of penicillin allergy. Manifestations may include urticarial or maculopapular rash, bronchospasm, and drug fever. Anaphylaxis, including severe hypotension and cardiac arrest, is reported.

Rare cases of renal insufficiency associated with cephalothin may be hypersensitivity-mediated since fever, eosinophilia, and rash are often also present.

A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.

Renal

Predisposing risk factors for nephrotoxicity include preexisting renal insufficiency, concomitant use of other potentially nephrotoxic drugs, and dehydration. Renal biopsy results in patients with suspected cephalothin-induced renal insufficiency have shown tubulo-interstitial nephritis. The mechanism may be hypersensitivity-mediated.

Renal side effects including renal insufficiency is rarely reported during therapy with most cephalosporins. Nephrotoxicity appears to be slightly more likely during cephalothin therapy, however. Risk factors include concomitant aminoglycoside therapy, preexisting renal insufficiency, elevated serum aminoglycoside levels, and high dose cephalothin therapy. Cephalothin may worsen renal function in patients with renal insufficiency. Frequent monitoring of the serum creatinine, maintenance of intravascular volume, and avoidance of potentially nephrotoxic agents during cephalothin therapy is recommended.

Hematologic

Hematologic side effects include thrombocytopenia, hemolytic anemia, and rare cases of pancytopenia.

One case of reversible aplastic anemia associated with cephalothin has been reported.

Gastrointestinal

Gastrointestinal side effects are unusual. Rare cases of pseudomembranous colitis associated with cephalothin (the active ingredient contained in Keflin) are reported.

Hepatic

Hepatic side effects are rare. Increases in serum transaminases associated with cephalothin (the active ingredient contained in Keflin) are reported.

Nervous system

In rare cases of suspected cephalothin-associated confusion, cerebrospinal fluid has been sterile, but has, in rare cases shown high levels of drug.

Nervous system side effects are rare, and include reports of delirium and confusion.

Other

The incidence of phlebitis may be reduced by frequent intravenous site care and the addition of heparin 500 units and hydrocortisone 10 mg to each liter of intravenous cephalothin (the active ingredient contained in Keflin)

Intravenous site phlebitis has been reported in up to 55% of patients.

Women may experience an increased incidence of vaginal yeast infections while receiving cephalothin.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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