Invega Side Effects
Generic Name: paliperidone
Please note - some side effects for Invega may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).
Side Effects of Invega - for the Consumer
Invega
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Invega:
Seek medical attention right away if any of these SEVERE side effects occur when using Invega:Dizziness; drowsiness; dry mouth; headache; lightheadedness; restlessness; weight gain.
TopSevere allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thoughts; behavior changes; chest pain; confusion; decreased sexual ability; decreased urination; enlarged breasts; fainting; fast or irregular heartbeat; fever; increased saliva production or drooling; increased sweating; mental/mood changes; missed menstrual period; muscle pain, weakness, or stiffness; nipple discharge; prolonged, painful erection; seizures; severe or prolonged dizziness or headache; shortness of breath; suicidal thoughts or attempts; symptoms of high blood sugar (eg, increased thirst, hunger, or urination; unusual weakness); tremor; trouble concentrating, speaking, or swallowing; trouble sitting still; trouble walking or standing; uncontrolled muscle movements (eg, arm or leg movements, twitching of the face or tongue, jerking or twisting); unusual eye movements.
Invega Side Effects - for the Professional
Invega
Most common adverse reactions (incidence ≥ 5% and at least twice that for placebo): akathisia and extrapyramidal disorder. (6)
To report SUSPECTED ADVERSE REACTIONS, contact Janssen, L.P. at 1-800-JANSSEN (1-800-526-7736) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch
Side Effects by Body System
Cardiovascular
Cardiovascular side effects including tachycardia (up to 14%), prolonged QTc interval (up to 5%), orthostatic hypotension (up to 4%), bundle branch block (up to 3%), first degree atrioventricular block (up to 2%), increased blood pressure (up to 2%), abnormal electrocardiogram T wave (up to 2%), and sinus arrhythmia (up to 2%) have been reported. Palpitations have been reported frequently. Bradycardia has been reported infrequently. Ischemia and venous thrombosis have been reported rarely. A case of atrial fibrillation has also been reported.
Nervous system
Nervous system side effects including headache (up to 14%), somnolence (up to 11%), akathisia (up to 10%), hyperkinesia (up to 9.9%), dyskinesia (up to 8.7%), Parkinsonism (up to 7.3%), extrapyramidal disorder (up to 7%), dizziness (up to 6%), dystonia (up to 5.3%), tremor (up to 4.5%), and hypertonia (up to 4%) have been reported. Abnormal coordination has been reported rarely. An apparent new onset grand mal seizure has also been reported.
The Dyskinesia group included dyskinesia, extrapyramidal disorder, muscle twitching, and tardive dyskinesia.
The dystonia group included dystonia, muscle spasms, oculogyration, and trismus.
The hyperkinesia group included akathisia, and hyperkinesia.
The Parkinsonism group included bradykinesia, cogwheel rigidity, drooling, hypertonia, hypokinesia, muscle rigidity, musculoskeletal stiffness, and Parkinsonism
Psychiatric
Psychiatric side effects including anxiety (up to 9%) have been reported. A confusional state has been reported infrequently.
Gastrointestinal
Gastrointestinal side effects including nausea (up to 6%), dyspepsia (up to 5%), salivary hypersecretion (up to 4%) upper abdominal pain (up to 3%), and dry mouth (up to 3%) have been reported. Abdominal pain has been reported frequently. Swollen tongue has been reported infrequently.
Respiratory
Respiratory side effects including cough (up to 3%) have been reported. Dyspnea has been reported frequently. Pulmonary embolus has been reported rarely.
General
General side effects including asthenia (up to 2%), fatigue (up to 2 %), and pyrexia (up to 2%) have been reported. Edema has been reported infrequently.
Metabolic
Metabolic side effects including increased blood insulin levels (up to 2%) have been reported.
Musculoskeletal
Musculoskeletal side effects including back pain (up to 2%) and pain in extremity (up to 2%) have been reported.
Ocular
Ocular side effects including blurred vision (up to 2%) have been reported.
Hematologic
Hematologic side effects including thrombocytopenia have been reported rarely.
Hypersensitivity
Hypersensitivity side effects including anaphylactic reaction have been reported rarely.
Endocrine
Endocrine side effects including increases in serum prolactin have been reported.
Other
Other side effects have included weight gain with use of the 9 mg and 12 mg daily dose.
Oncologic
Oncologic side effects have included statistically significant increases in pituitary gland adenomas, endocrine pancreas adenomas, and mammary gland adenocarcinomas which have been reported in animal studies with risperidone (which is converted to paliperidone).
TopDisclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
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