Ceftin Side Effects
Generic name: cefuroxime
Note: This document contains side effect information about cefuroxime. Some of the dosage forms listed on this page may not apply to the brand name Ceftin.
Some side effects of Ceftin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to cefuroxime: oral powder for suspension, oral tablet
Other dosage forms:
Along with its needed effects, cefuroxime (the active ingredient contained in Ceftin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking cefuroxime:More common
- general feeling of illness or discomfort
- itching of the vagina or genital area
- pain during sexual intercourse
- thick, white vaginal discharge with no odor or with a mild odor
- Black, tarry stools
- chest pain
- loose stools
- painful or difficult urination
- shortness of breath
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- unusual bleeding or bruising
- unusual tiredness or weakness
- Back, leg, or stomach pains
- bladder pain
- bleeding gums
- bloody or cloudy urine
- body aches or pain
- burning while urinating
- dark urine
- difficulty with breathing
- ear congestion
- fast, pounding, or irregular heartbeat or pulse
- frequent urge to urinate
- general body swelling
- loss of appetite
- loss of voice
- lower back or side pain
- nasal congestion
- nausea or vomiting
- pain or tenderness around the eyes and cheekbones
- pale skin
- pink or red urine
- stuffy or runny nose
- swelling of the joints
- swollen glands
- tightness of chest or wheezing
- white or brownish vaginal discharge
- white patches in the mouth or throat or on the tongue
- white patches with diaper rash
- yellowing of the eyes or skin
- Blistering, peeling, or loosening of the skin
- bloody, black, or tarry stools
- clay-colored stools
- cough or hoarseness
- coughing up blood
- decrease in urine output or decrease in urine-concentrating ability
- feeling of discomfort
- fever with or without chills
- general feeling of tiredness or weakness
- high fever
- increased menstrual flow or vaginal bleeding
- joint or muscle pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- light-colored stools
- prolonged bleeding from cuts
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red or black, tarry stools
- red or dark brown urine
- red skin lesions, often with a purple center
- red, irritated eyes
- swollen lymph glands
- swollen or painful glands
- unpleasant breath odor
- upper right abdominal or stomach pain
- vomiting of blood
Some side effects of cefuroxime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
- Bad, unusual, or unpleasant (after) taste
- change in taste
- diaper rash
- Abdominal or stomach cramps
- acid or sour stomach
- difficulty with moving
- excess air or gas in the stomach or intestines
- flushing or redness of the skin
- full feeling
- gas in the stomach
- irritation or soreness of the mouth
- itching skin
- muscle pain or stiffness
- muscle spasm of the neck
- passing gas
- sleepiness or unusual drowsiness
- stomach discomfort, upset, or pain
- swelling of the tongue
- trouble sitting still
- unusually warm skin
- watering of the mouth and drooling
- weight loss
- Hives or welts
- redness of the skin
For Healthcare Professionals
Applies to cefuroxime: injectable powder for injection, intravenous solution, oral powder for reconstitution, oral tablet
Cefuroxime (the active ingredient contained in Ceftin) is generally well-tolerated.
Side effects may be more likely and more severe in patients with liver disease and/or renal dysfunction.
Gastrointestinal side effects have included nausea and vomiting (1% to 3%), diarrhea/loose stools (1% to 8.6%), abdominal pain, abdominal cramps, flatulence, indigestion, mouth ulcers, and anorexia, dyspepsia, excess salivation, and pseudomembranous colitis.
Pseudomembranous colitis has been reported in patients treated with cephalosporins, including cefuroxime, and may occur during or after treatment. If diarrhea occurs and it is unresponsive to discontinuation of the drug and/or standard therapy, pseudomembranous colitis should be considered.
Hepatic side effects have included transient elevations of AST (2% to 4%), ALT (1.6% to 4%), and LDH (1%), alkaline phosphatase (2%, IV route), elevated bilirubin, hepatitis, cholestasis, and jaundice.
Nervous system side effects have included headache, sleepiness, dizziness, somnolence, lockjaw-type reaction (less than 1%), and seizures. Cephalosporin class antibiotics, including cefuroxime (the active ingredient contained in Ceftin) have been associated with seizures, especially in renally impaired patients.
Hypersensitivity reactions have included anaphylaxis, angioedema, rash, pruritus, serum sickness-like reaction, urticaria, drug fever, interstitial nephritis, toxic epidermal necrolysis, and Stevens-Johnson syndrome. At least one case of Kounis syndrome type I variant has been reported.
Rare cases of erythema multiforme and Stevens-Johnson syndrome have been reported. There is a 10% to 20% incidence of allergy to cefuroxime in patients allergic to penicillin.
A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.
A 90-year-old man, with no history of coronary artery disease, diabetes mellitus, hypertension, or hyperlipidemia, was administered 750 mg cefuroxime axetil intramuscularly for urinary tract infection. About 10 minutes after the injection, the patient developed chest pain and pruritic skin rashes. Kounis syndrome type I variant was diagnosed secondary to cefuroxime axetil. Five days after stopping cefuroxime axetil, the patient's symptoms had resolved.
Hematologic side effects have included eosinophilia (1.1%), positive Coombs' test (less than 1%), decreased hemoglobin and hematocrit (10%, IV route), transient neutropenia (less than 1%), leukopenia (0.1%), hemolytic anemia, pancytopenia, increased prothrombin time, thrombocytopenia, and autoimmune granulocytopenia. Cephalosporin class antibiotics have been associated with aplastic anemia, hemorrhage, neutropenia, and agranulocytosis.
Rare cases of eosinophilia and positive direct Coombs' tests have been reported without other evidence of hypersensitivity.
Immune hemolytic anemia has been reported in a pediatric patient.
Acute renal failure has been reported in a patient treated with cefuroxime (the active ingredient contained in Ceftin) Renal function improved after cefuroxime was stopped, and deteriorated upon rechallenge.
Renal side effects have included renal dysfunction (less than 1%) and acute renal failure. Cephalosporin class antibiotics have been associated with toxic nephropathy, increased BUN, increased creatinine, and interstitial nephritis. Reversible fever, azotemia, pyuria, and eosinophilia are the hallmarks of cephalosporin-induced interstitial nephritis.
Genitourinary side effects have included vaginitis, vaginal candidiasis, vaginal discharge, vaginal itch, vulvar itch, dysuria, urethral pain and/or bleeding, and kidney pain in less than 1% of patients, and urinary tract infection (less than 1% of pediatric patients). Cephalosporin class antibiotics have been associated with false positive tests for urinary glucose.
Dermatologic side effects have included rash, hives, pruritus, urticaria, and erythema in less than 1% of patients, diaper rash (3.4% of pediatric patients), acute generalized exanthematous pustulosis, erythema multiforme, and toxic epidermal necrolysis.
Metabolic side effects have included thirst (less than 1%).
Other side effects have included chest pain or tightness, chills, viral illness, gastrointestinal infection, swollen tongue, candidiasis, and fever in less than 1% of patients. At least one case of disulfiram reaction has been reported with cefuroxime (the active ingredient contained in Ceftin) axetil. Complaints about taste were reported in 5% of pediatric patients, leading to discontinuation in 1.4%.
The Jarisch-Herxheimer reaction has been reported in 5.6% of Lyme Disease patients.
Respiratory side effects have included shortness of breath (less than 1%), and sinusitis, cough, and upper respiratory infection in less than 1% of pediatric patients.
Musculoskeletal side effects have included muscle cramps, muscle stiffness, and muscle spasm of the neck in less than 1% of patients, and joint swelling and arthralgia in less than 1% of pediatric patients.
Cardiovascular side effects have included tachycardia (less than 1%).
Local side effects have included thrombophlebitis with intravenous administration (1.7%).
Immunologic side effects have included cutaneous vasculitis (postmarketing experience).
More Ceftin resources
- Ceftin Prescribing Information (FDA)
- Ceftin Consumer Overview
- Ceftin Advanced Consumer (Micromedex) - Includes Dosage Information
- Ceftin MedFacts Consumer Leaflet (Wolters Kluwer)
- cefuroxime MedFacts Consumer Leaflet (Wolters Kluwer)
- Cefuroxime Professional Patient Advice (Wolters Kluwer)
- Cefuroxime Axetil Monograph (AHFS DI)
- Zinacef Prescribing Information (FDA)
- Zinacef Advanced Consumer (Micromedex) - Includes Dosage Information
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