Bumetanide Side Effects

Not all side effects for bumetanide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to bumetanide: oral tablet

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by bumetanide. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking bumetanide:

More common
  • Abdominal pain
  • blurred vision
  • confusion
  • decreased urine output
  • dizziness
  • drowsiness
  • dry mouth
  • fast or irregular heartbeat
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • irritability
  • joint pain, stiffness, or swelling
  • loss of appetite
  • loss of mental alertness
  • lower back, side, or stomach pain
  • mood or mental changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • shortness of breath
  • sweating
  • swelling of face, hands, feet, ankles, or lower legs
  • troubled breathing
  • unexplained weight loss
  • unusual tiredness or weakness
  • weak pulse
Rare
  • Agitation
  • back pain
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • chest pain
  • convulsions (seizures)
  • deep or fast breathing with dizziness
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • fever
  • hallucinations
  • hives
  • increase in heart rate
  • increased blood pressure
  • numbness of feet, hands, and around the mouth
  • pinpoint red spots on the skin
  • rapid breathing
  • stiff neck
  • sunken eyes
  • trembling, jerking of hands
  • unusual bleeding or bruising
  • weight gain
  • wrinkled skin

If any of the following symptoms of overdose occur while taking bumetanide, get emergency help immediately:

Symptoms of overdose
  • Difficulty breathing
  • pain in chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath
  • unusual drowsiness, dullness, or feeling of sluggishness
  • vision changes

Some of the side effects that can occur with bumetanide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Rare
  • Decreased interest in sexual intercourse
  • diarrhea
  • difficulty with moving
  • ear discomfort
  • feeling of constant movement of self or surroundings
  • inability to have or keep an erection
  • itching skin
  • loss in sexual ability, desire, drive, or performance
  • muscle or bone pain
  • muscle stiffness
  • nipple tenderness
  • pain, swelling, or redness in joints
  • rash
  • sensation of spinning
  • shorter than usual time to ejaculation of semen
  • trouble with hearing
  • upset stomach

For Healthcare Professionals

Applies to bumetanide: compounding powder, injectable solution, oral tablet

Metabolic

Metabolic side effects associated with bumetanide, as with other loop diuretics, occur in 7% to 20% of patients, and include hyponatremia, hypokalemia, hypochloremia, and hyperuricemia. These side effects may be more likely in patients with renal insufficiency. Glucose intolerance is reported in up to 14% of elderly patients. Hypokalemia may lead to increased renal tubular bicarbonate reabsorption, resulting in metabolic alkalosis.

Besides acting on the loop of Henle, bumetanide also inhibits phosphate reabsorption in the proximal tubule, resulting in phosphaturia. Since phosphorous is abundant in most diets, bumetanide-induced phosphaturia may not be significant except in malnourished patients, patients on life support, and patients with significant muscle weakness.

Calcium balance appears to remain neutral during treatment with a loop diuretic (i.e., furosemide, bumetanide). Although loop diuretics cause an increase in renal calcium excretion, this appears to be compensated for by a parathyroid-dependent increase in 1,25-dihydroxyvitamin D levels, which increases intestinal calcium absorption. Bone metabolism does not appear to be significantly affected by loop diuretics.

Musculoskeletal

Musculoskeletal side effects have included muscle cramps in 1.1% and weakness in 0.2% of patients.

Renal

Renal insufficiency, manifested as a rise in serum creatinine and BUN, may occur in up to 7% of patients. It is usually due to extracellular fluid volume depletion and is readily reversible.

Cardiovascular

Cardiovascular side effects include hypotension in less than 2% of patients. Patients with a history of cardiac arrhythmias should be monitored closely because of the risk of hypokalemia.

Gastrointestinal

Gastrointestinal side effects were reported in less than 2% of patients and included nausea, vomiting, loose stools, and constipation. There have been rare reports of hyperamylasemia and pancreatitis associated with bumetanide use.

Nervous system

Nervous system side effects, such as headache, dizziness, deafness, tinnitus, vertigo, and decreased hearing, are reported in less than 2% of patients. Encephalopathy after bumetanide administration is reported in patients with severe liver disease.

Hypersensitivity

Severe hypersensitivity reactions such as Stevens-Johnson syndrome and recurrent urticaria have been reported in rare cases.

Hypersensitivity reactions are rare. Rash is reported in less than 1% of treated patients. Because cross-reactivity with furosemide is rare, bumetanide can be substituted at about a 1:40 dose ratio of bumetanide to furosemide in patients allergic to furosemide.

Dermatologic

Dermatologic side effects have included pseudoporphyria, Stevens-Johnson syndrome, and toxic epidermal necrolysis.

Hematologic

Hematologic side effects are extremely rare. Cases of thrombocytopenia, mild anemia, and leukopenia have been reported.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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