Loop diuretics

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Loop diuretics inhibit the Na+/K+/2Cl- co-transporter in the thick ascending loop of Henle, in the kidneys and stop the transport of sodium chloride out of the tubule into the interstitial tissue, causing a decrease in sodium and chloride re-absorption. They act on the chloride-binding site and have a direct inhibiting effect on the carrier.

Inhibition of this transporter leads to a significant increase in concentration of ions in the tubule and reduced hypertonicity in the surrounding interstitium, causing less water to be reabsorbed into the blood. This causes more urine to be produced and a decrease in blood volume.

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