Generic Name: vincristine liposome (vin KRIS teen LYE poe some)
Brand Names: Marqibo
What is Marqibo?
Marqibo (vincristine liposome) is cancer medication that interferes with the growth of cancer cells and slows their spread in the body.
Marqibo is used to treat a type of blood cancer called Philadelphia chromosome negative acute lymphoblastic leukemia (ALL). It is usually given after at least two other cancer medications have been tried without success.
Marqibo may also be used for purposes not listed in this medication guide.
You should not use Marqibo if you have Charcot-Marie-Tooth syndrome or other conditions that cause damage to myelin (protective covering of the nerves in your brain and spinal cord).
Before receiving Marqibo
You should not use Marqibo if you are allergic to vincristine, or if you have Charcot-Marie-Tooth syndrome or other conditions that cause damage to myelin (protective covering of the nerves in your brain and spinal cord).
To make sure Marqibo is safe for you, tell your doctor if you have:
a nerve-muscle disorder such as myasthenia gravis, ALS (Lou Gehrig's disease), multiple sclerosis, or muscular dystrophy;
peripheral vascular disease such as Raynaud's syndrome;
a bowel obstruction called paralytic ileus;
coronary artery disease.
Marqibo can cause harm to an unborn baby or cause birth defects. Before you receive Marqibo, tell your doctor if you are pregnant. Use effective birth control to avoid pregnancy during your treatment with Marqibo. Follow your doctor's instructions about how long to prevent pregnancy after your treatment ends.
Vincristine liposome can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
How is Marqibo given?
Marqibo is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion.
Marqibo can cause severe constipation. You may be given medication to prevent constipation while you are receiving this medicine. Use all medications as directed by your doctor.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.
Marqibo can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your Marqibo injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid?
Marqibo may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.
Do not receive a "live" vaccine while using Marqibo, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
Vincristine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Marqibo side effects
Get emergency medical help if you have any signs of an allergic reaction to Marqibo: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe constipation, severe cramps;
pale skin, feeling light-headed or short of breath, rapid heart rate, feeling very weak or tired;
numbness, tingling, or burning pain in your hands or feet;
fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
lower back pain, blood in your urine, little or no urinating;
tingly feeling around your mouth, muscle weakness, tightness, or contraction, overactive reflexes;
fast or slow heart rate, weak pulse, confusion, fainting; or
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common Marqibo side effects may include:
nausea, loss of appetite; or
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Marqibo dosing information
Usual Adult Dose for Acute Lymphoblastic Leukemia:
2.25 mg/m2 intravenously over 1 hour every 7 days.
What other drugs will affect Marqibo?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Marqibo, especially:
clozapine, conivaptan, deferiprone, natalizumab, nefazodone; or
an antibiotic--clarithromycin, erythromycin, telithromycin; antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole; HIV/AIDS medication--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir; hepatitis C medications--boceprevir, telaprevir.
This list is not complete. Other drugs may interact with Marqibo, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Where can I get more information?
- Your doctor or pharmacist can provide more information about Marqibo.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Marqibo only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2015 Cerner Multum, Inc. Version: 1.02. Revision Date: 2015-08-04, 3:08:21 PM.