Generic Name: vincristine liposome (vin KRIS teen LYE poe some)
Brand Name: Marqibo
What is vincristine liposome?
Vincristine liposome is cancer medication that interferes with the growth of cancer cells and slows their spread in the body.
Vincristine liposome is used to treat a type of blood cancer called Philadelphia chromosome negative acute lymphoblastic leukemia (ALL).
Vincristine liposome is usually given after at least two other cancer medications have been tried without success.
Vincristine liposome may also be used for purposes not listed in this medication guide.
What is the most important information I should know about vincristine liposome?
You should not use this medication if you have Charcot-Marie-Tooth syndrome or other conditions that cause damage to myelin (protective covering of the nerves in your brain and spinal cord).
What should I discuss with my healthcare provider before receiving vincristine liposome?
You should not use this medication if you are allergic to vincristine, or if you have Charcot-Marie-Tooth syndrome or other conditions that cause damage to myelin (protective covering of the nerves in your brain and spinal cord).
To make sure vincristine liposome is safe for you, tell your doctor if you have:
a nerve-muscle disorder such as myasthenia gravis, ALS (Lou Gehrig's disease), multiple sclerosis, or muscular dystrophy;
peripheral vascular disease such as Raynaud's syndrome;
a bowel obstruction called paralytic ileus;
coronary artery disease.
FDA pregnancy category D. Vincristine liposome can cause harm to an unborn baby or cause birth defects. Before you receive vincristine liposome, tell your doctor if you are pregnant. Use effective birth control to avoid pregnancy during your treatment with vincristine liposome. Follow your doctor's instructions about how long to prevent pregnancy after your treatment ends.
Vincristine liposome can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
How is vincristine liposome given?
Vincristine liposome is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion.
Vincristine liposome can cause severe constipation. You may be given medication to prevent constipation while you are receiving this medicine. Use all medications as directed by your doctor.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.
Vincristine liposome can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your vincristine liposome injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving vincristine liposome?
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.
Do not receive a "live" vaccine while using vincristine liposome, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
This medicine can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Patients and caregivers should wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
Vincristine liposome side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe constipation, severe cramps;
pale skin, feeling light-headed or short of breath, rapid heart rate, feeling very weak or tired;
numbness, tingling, or burning pain in your hands or feet;
fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
lower back pain, blood in your urine, little or no urinating;
tingly feeling around your mouth, muscle weakness, tightness, or contraction, overactive reflexes;
fast or slow heart rate, weak pulse, confusion, fainting; or
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
nausea, loss of appetite; or
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: vincristine liposome side effects (in more detail)
Vincristine liposome Dosing Information
Usual Adult Dose for Acute Lymphoblastic Leukemia:
2.25 mg/m2 intravenously over 1 hour every 7 days.
What other drugs will affect vincristine liposome?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with vincristine liposome, especially:
clozapine, conivaptan, deferiprone, natalizumab, nefazodone; or
an antibiotic--clarithromycin, erythromycin, telithromycin; antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole; HIV/AIDS medication--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir; hepatitis C medications--boceprevir, telaprevir.
This list is not complete. Other drugs may interact with vincristine liposome, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More vincristine liposome resources
- vincristine liposome Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
- Marqibo Prescribing Information (FDA)
- Marqibo injection MedFacts Consumer Leaflet (Wolters Kluwer)
- Marqibo Consumer Overview
Compare vincristine liposome with other medications
Where can I get more information?
- Your doctor or pharmacist can provide more information about vincristine liposome.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 1.01. Revision Date: 2013-07-10, 8:49:24 AM.