Marqibo Side Effects

Generic Name: vincristine liposome

Note: This document contains side effect information about vincristine liposome. Some of the dosage forms listed on this page may not apply to the brand name Marqibo.

Some side effects of Marqibo may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to vincristine liposome: intravenous solution, intravenous suspension

Along with its needed effects, vincristine liposome (the active ingredient contained in Marqibo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking vincristine liposome:

More common
  • Abdominal or stomach pain
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • blurred vision
  • burning, tingling, numbness or pain in the hands, arms, feet, or legs
  • change in consciousness
  • change in muscle reflexes
  • chest pain
  • chills
  • confusion
  • cough
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fever
  • increased sensitivity to pain or touch
  • low blood pressure or pulse
  • lower back or side pain
  • nerve pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • sensation of pins and needles
  • severe constipation
  • severe vomiting
  • shortness of breath
  • sneezing
  • sore throat
  • stabbing pain
  • sweating
  • tightness in the chest
  • troubled breathing
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common
  • Blue lips, fingernails, or skin
  • irregular, fast or slow, or shallow breathing
Incidence not known
  • Abdominal or stomach tenderness
  • clay colored stools
  • dark urine
  • decreased appetite
  • headache
  • itching
  • joint pain, stiffness, or swelling
  • loss of appetite
  • nausea and vomiting
  • skin rash
  • swelling of the feet or lower legs
  • yellow eyes or skin

Some side effects of vincristine liposome may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Lack or loss of strength
  • mental depression or anxiety
  • muscle weakness
  • nightmares or unusually vivid dreams
Incidence not known
  • Redness, pain, or swelling at the injection site

For Healthcare Professionals

Applies to vincristine liposome: intravenous kit

Cardiovascular

Frequency not reported: Hypotension, cardiac arrest

Gastrointestinal

Very common (10% or more): Constipation (57%), nausea (52%), diarrhea (37%), decreased appetite (33%)
Frequency not reported: Abdominal pain, ileus/colonic pseudo-obstruction

General

Side effects that have resulted in non-leukemia related deaths: Brain infarct, intracerebral hemorrhage, liver failure, multisystem organ failure, pneumonia and septic shock, respiratory failure, pulmonary hemorrhage, sudden cardiac death

Hematologic

Very common (10% or more): Febrile neutropenia (38%), neutropenia (31.3%), anemia (34%), thrombocytopenia (16.9%)
Frequency not reported: Neutropenia, thrombocytopenia, Tumor lysis syndrome

Metabolic

Frequency not reported: Increased aspartate aminotransferase

Musculoskeletal

Frequency not reported: Asthenia, muscular weakness, musculoskeletal pain

Nervous system

Very common (10% or more): Peripheral neuropathy (39%), insomnia (32%)
Frequency not reported: Peripheral sensory and motor neuropathy, decreased vibratory sense, facial palsy, hyporeflexia

Other

Very common (10% or more): Pyrexia (43%), fatigue (41%)
Frequency not reported: Pain, septic shock, staphylococcal bacteremia

Psychiatric

Frequency not reported: Mental status changes

Respiratory

Frequency not reported: Pneumonia, respiratory distress, respiratory failure

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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