Generic Name: lurasidone (loo RAS i done)
Brand Names: Latuda

What is Latuda?

Latuda (lurasidone) is an antipsychotic medication. It works by changing the effects of chemicals in the brain.

Latuda is used to treat schizophrenia in adults.

Latuda may also be used for purposes not listed in this medication guide.

Important information

Latuda is not for use in psychotic conditions related to dementia. Latuda may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use this medicine if you are allergic to lurasidone, or if you are also using ketoconazole (Extina, Ketozole, Nizoral, Xolegal) or rifampin (Rifater, Rifadin, Rifamate).

Before you take Latuda, tell your doctor if you have liver disease, kidney disease, heart disease, high blood pressure, heart rhythm problems, a history of heart attack or stroke, high cholesterol or triglycerides, low white blood cell (WBC) counts, seizures, diabetes, Parkinson's disease, trouble swallowing, or a history of breast cancer or suicidal thoughts.

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While you are taking Latuda, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking Latuda.

Latuda may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Drinking alcohol can increase certain side effects of Latuda. Stop using this medicine and call your doctor at once if you have very stiff (rigid) muscles, high fever, sweating, confusion, fast or pounding heartbeats, feeling like you might pass out, tremors, or twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs.

Before taking this medicine

You should not use Latuda if you are allergic to lurasidone, or if you are also using ketoconazole (Nizoral) or rifampin (Rifater, Rifadin, Rifamate).

Latuda is not approved for use in psychotic conditions related to dementia. Lurasidone may increase the risk of death in older adults with dementia-related conditions.

Long-term use of Latuda can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. The longer you take Latuda, the more likely you are to develop this movement disorder. The risk of this side effect is higher in women and older adults.

To make sure Latuda is safe for you, tell your doctor if you have:

  • liver disease;

  • kidney disease;

  • heart disease, high blood pressure, heart rhythm problems;

  • a history of heart attack or stroke;

  • high cholesterol or triglycerides (a type of fat in the blood);

  • low white blood cell (WBC) counts;

  • a history of breast cancer;

  • seizures or epilepsy;

  • personal or family history of diabetes (Latuda may raise your blood sugar);

  • a history of suicidal thoughts or actions;

  • Parkinson's disease; or

  • trouble swallowing.

FDA pregnancy category B. Latuda is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

See also: Pregnancy and breastfeeding warnings (in more detail)

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Latuda, do not stop taking it without your doctor's advice.

It is not known whether lurasidone passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not give this medicine to anyone under 18 years old without medical advice.

How should I take Latuda?

Take Latuda exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Latuda should be taken with food (at least 350 calories).

Use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

It may take several weeks before your symptoms improve. Keep using the medication as directed. Call your doctor if your symptoms do not improve, or if they get worse while using Latuda.

Store at room temperature away from moisture and heat.

Latuda Dosing Information

Usual Adult Dose for Schizophrenia:

Initial dose: 40 mg orally once daily. Initial dose titration is not required.
Maximum dose: 160 mg once daily.

Comments: Should be taken with food (at least 350 calories). Administration with food substantially increases drug absorption.

Approved indication: Schizophrenia

Usual Adult Dose for Bipolar Disorder:

Initial dose: 20 mg orally once daily as monotherapy or as adjunctive therapy with lithium or valproate. Initial dose titration is not required.
Maximum dose: 120 mg once daily as monotherapy or as adjunctive therapy with lithium or valproate.

Comments: Should be taken with food (at least 350 calories). Administration with food substantially increases drug absorption.

Approved indication: Depressive episodes associated with Bipolar I Disorder

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Latuda?

While you are taking Latuda, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking Latuda.

Latuda may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Drinking alcohol can increase certain side effects of Latuda.

Latuda side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Latuda: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • dizziness, fainting, fast or pounding heartbeats;

  • agitation, hostility, confusion, thoughts about hurting yourself;

  • seizure (convulsions);

  • sudden weakness or ill feeling, fever, chills, sore throat, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough;

  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);

  • high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss; or

  • severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common Latuda side effects may include:

  • drowsiness;

  • nausea;

  • feeling restless or agitated; or

  • tremors, shaking, problems with balance or walking.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Latuda?

Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking Latuda with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Latuda, especially:

  • St. John's wort;

  • an antibiotic - clarithromycin, erythromycin, telithromycin;

  • antifungal medicine - itraconazole, voriconazole;

  • the hepatitis C medicines, boceprevir or telaprevir;

  • HIV or AIDS medicines - atazanavir, cobicistat (Stribild), darunavir, delavirdine, fosamprenavir, indinavir, ritonavir, saquinavir; or

  • seizure medicine - carbamazepine, phenobarbital, phenytoin.

This list is not complete. Other drugs may interact with lurasidone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about Latuda.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 4.01. Revision Date: 2014-07-14, 11:54:29 AM.

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