Loxapine Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Schizophrenia

Initial Dose: 10 mg twice daily is recommended, although in severely disturbed patients initial dosage up to a total of 50 mg daily may be desirable. Dosage should then be increased fairly rapidly over the first seven to ten days until there is effective control of symptoms of schizophrenia.

Maintenance Dose: 60 mg to 100 mg daily. However, some patients respond to lower dosage and others may require higher dosage for optimal benefit.

Maximum dose: 250 mg/day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Loxapine should be used with extreme caution in patients with a history of convulsive disorders since it lowers the convulsive threshold.

Loxapine should be used with caution in patients with cardiovascular disease. Increased pulse rates have been reported in the majority of patients receiving antipsychotic doses; transient hypotension has been reported. In the presence of severe hypotension requiring vasopressor therapy, the preferred drugs may be norepinephrine or angiotensin. Usual doses of epinephrine may be ineffective because of inhibition of its vasopressor effect by loxapine.

Loxapine should be used with caution in patients with glaucoma or urinary retention.

There is a slightly higher incidence of extrapyramidal effects following intramuscular administration than normally anticipated with oral formulations. The increase may be attributable to higher plasma levels following intramuscular injection.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Loxapine is contraindicated in comatose or severe drug-induced depressed states (alcohol, barbiturates, narcotics, etc.).

Loxapine is contraindicated in individuals with known hypersensitivity to dibenzoxazepines.

Dialysis

Data not available

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