Loxapine Side Effects
Some side effects of loxapine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to loxapine: oral capsule
Get emergency medical help if you have any of these signs of an allergic reaction while taking loxapine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using loxapine and call your doctor at once if you have:
very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out;
restless muscle movements in your eyes, tongue, jaw, or neck;
tremor (uncontrolled shaking);
easy bruising or bleeding, unusual weakness;
fever, chills, body aches, flu symptoms;
severe constipation; or
little or no urinating.
Other common side effects may include:
dizziness or drowsiness;
puffiness in your face;
feeling restless or agitated;
sleep problems (insomnia);
breast swelling or discharge;
changes in your menstrual periods;
nausea, vomiting, constipation;
changes in weight;
dry mouth, stuffy nose; or
mild skin rash, itching, or flaking.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to loxapine: inhalation powder, intramuscular solution, oral capsule, oral concentrate
Nervous system side effects including Neuroleptic malignant syndrome (NMS), agitation, drowsiness, dizziness, faintness, staggering gait, tremor, shuffling gait, muscle twitching, weakness, insomnia, tension, rigidity, excessive salivation, akathisia, muscle spasms in neck and face, tongue protrusion, seizures, akinesia, paresthesia, slurred speech, numbness, and confusion have been frequently reported.
Cardiovascular side effects including tachycardia, hypotension, hypertension, orthostatic hypotension, light-headedness, increased pulse rate, and syncope have been reported.
Gastrointestinal side effects including nausea, vomiting, and constipation have been reported.
Hematologic side effects including agranulocytosis, thrombocytopenia, and leukopenia have rarely been reported.
Genitourinary side effects including urinary retention, increase in prolactin levels, galactorrhea, amenorrhea, gynecomastia, and menstrual irregularity have been reported.
Ocular side effects including blurred vision, oculogyric movement, ptosis, pigmentary retinopathy, and lenticular pigmentation have been reported.
Hepatic side effects including hepatocellular injury, increased SGOT/SGPT levels, jaundice, and hepatitis have rarely been reported.
Dermatologic side effects including dermatitis, edema, pruritus, rash, alopecia, and seborrhea have been reported.
Respiratory side effects including dyspnea have been infrequently reported.
General side effects including dry mouth, weight gain, weight loss, headache, hyperpyrexia, and polydipsia have been reported.
More loxapine resources
- loxapine MedFacts Consumer Leaflet (Wolters Kluwer)
- loxapine Advanced Consumer (Micromedex) - Includes Dosage Information
- Loxapine Professional Patient Advice (Wolters Kluwer)
- Loxapine Prescribing Information (FDA)
- Adasuve Prescribing Information (FDA)
- Adasuve Consumer Overview
- Loxapine Succinate Monograph (AHFS DI)
- Loxitane Prescribing Information (FDA)
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.