Loxapine Side Effects
Some side effects of loxapine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to loxapine: oral capsule, oral solution, oral tablet
Other dosage forms:
Along with its needed effects, loxapine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking loxapine:More common
- Difficulty with speaking or swallowing
- lip smacking or puckering
- loss of balance control
- mask-like face
- puffing of the cheeks
- rapid or fine, worm-like movements of the tongue
- restlessness or desire to keep moving
- shuffling walk
- slowed movements
- stiffness of the arms and legs
- trembling and shaking of the fingers and hands
- uncontrolled chewing movements
- uncontrolled movements of the arms or legs
- Constipation (severe)
- difficult urination
- inability to move the eyes
- muscle spasms, especially of the neck and back
- skin rash
- twisting movements of the body
- Convulsions (seizures)
- difficult or fast breathing
- fast heartbeat or irregular pulse
- fever (high)
- high or low blood pressure
- increased blinking or spasms of the eyelid
- increased sweating
- loss of bladder control
- muscle stiffness (severe)
- sore throat and fever
- uncontrolled twisting movements of neck, trunk, arms, or legs
- unusual bleeding or bruising
- unusual facial expressions or body positions
- unusual tiredness or weakness
- unusually pale skin
- yellow eyes or skin
Get emergency help immediately if any of the following symptoms of overdose occur while taking loxapine:Symptoms of overdose
- Dizziness (severe)
- drowsiness (severe)
- muscle trembling, jerking, stiffness, or uncontrolled movements (severe)
- troubled breathing (severe)
- unusual tiredness or weakness (severe)
Some side effects of loxapine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Blurred vision
- dizziness, lightheadedness, or fainting
- dryness of the mouth
- Constipation (mild)
- decreased sexual ability
- enlargement of breasts (males and females)
- increased sensitivity of the skin to sun
- missing menstrual periods
- nausea or vomiting
- trouble with sleeping
- unusual secretion of milk
- weight gain
For Healthcare Professionals
Applies to loxapine: inhalation powder, intramuscular solution, oral capsule, oral concentrate
Nervous system side effects including Neuroleptic malignant syndrome (NMS), agitation, drowsiness, dizziness, faintness, staggering gait, tremor, shuffling gait, muscle twitching, weakness, insomnia, tension, rigidity, excessive salivation, akathisia, muscle spasms in neck and face, tongue protrusion, seizures, akinesia, paresthesia, slurred speech, numbness, and confusion have been frequently reported.
Cardiovascular side effects including tachycardia, hypotension, hypertension, orthostatic hypotension, light-headedness, increased pulse rate, and syncope have been reported.
Gastrointestinal side effects including nausea, vomiting, and constipation have been reported.
Hematologic side effects including agranulocytosis, thrombocytopenia, and leukopenia have rarely been reported.
Genitourinary side effects including urinary retention, increase in prolactin levels, galactorrhea, amenorrhea, gynecomastia, and menstrual irregularity have been reported.
Ocular side effects including blurred vision, oculogyric movement, ptosis, pigmentary retinopathy, and lenticular pigmentation have been reported.
Hepatic side effects including hepatocellular injury, increased SGOT/SGPT levels, jaundice, and hepatitis have rarely been reported.
Dermatologic side effects including dermatitis, edema, pruritus, rash, alopecia, and seborrhea have been reported.
Respiratory side effects including dyspnea have been infrequently reported.
General side effects including dry mouth, weight gain, weight loss, headache, hyperpyrexia, and polydipsia have been reported.
More about loxapine
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