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Diflunisal Dosage

Medically reviewed by Drugs.com. Last updated on Oct 24, 2023.

Applies to the following strengths: 250 mg; 500 mg

Usual Adult Dose for Pain

Initial dose: 1000 mg orally once
Maintenance dose: 500 mg every 12 hours; some patients may require 500 mg every 8 hours
Maximum dose: 1500 mg/day

Comments: A lower dose may be appropriate depending on such factors as pain severity, patient response, weight, or advanced age; for example, 500 mg initially, followed by 250 mg every 8 to 12 hours.

Use: For the treatment of mild to moderate pain

Usual Adult Dose for Osteoarthritis

500 to 1000 mg orally per day in 2 divided doses

Comments:


Uses: For the treatment of osteoarthritis and rheumatoid arthritis

Usual Adult Dose for Rheumatoid Arthritis

500 to 1000 mg orally per day in 2 divided doses

Comments:


Uses: For the treatment of osteoarthritis and rheumatoid arthritis

Usual Pediatric Dose for Pain

12 years or older:


Comments: A lower dose may be appropriate depending on such factors as pain severity, patient response, weight, or advanced age; for example, 500 mg initially, followed by 250 mg every 8 to 12 hours.

Use: For the treatment of mild to moderate pain

Usual Pediatric Dose for Osteoarthritis

12 years or older: 500 to 1000 mg orally per day in 2 divided doses

Comments:


Uses: For the treatment of osteoarthritis and rheumatoid arthritis

Usual Pediatric Dose for Rheumatoid Arthritis

12 years or older: 500 to 1000 mg orally per day in 2 divided doses

Comments:


Uses: For the treatment of osteoarthritis and rheumatoid arthritis

Renal Dose Adjustments

Advanced renal dysfunction: Not recommended; if therapy is necessary, closely monitor renal function.

Liver Dose Adjustments

Dose Adjustments

Elderly patients may require lower doses due to increased risk for adverse effects and increased likelihood of concomitant renal impairment.

Precautions

US BOXED WARNINGS: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS:


Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.