Dexlansoprazole Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Erosive Esophagitis

Initial dose: 60 mg orally once a day for up to 8 weeks

Maintenance dose: 30 mg orally once a day for up to 6 months

Usual Adult Dose for Gastroesophageal Reflux Disease

For treatment of heartburn associated with non-erosive GERD: 30 mg once a day for 4 weeks

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Mild hepatic impairment (Child-Pugh A): No adjustment recommended

Moderate hepatic impairment (Child-Pugh B): Maximum daily dose should not exceed 30 mg.

Severe hepatic impairment (Child-Pugh C): No studies have been conducted

Precautions

Systemic exposure of dexlansoprazole is generally higher in intermediate and poor metabolizers of the polymorphic liver enzyme CYP450 2C19. In subjects who received a single dose of dexlansoprazole 30 mg or 60 mg, mean dexlansoprazole Cmax and AUC values were up to 2 times higher in intermediate compared to extensive metabolizers; in poor metabolizers, mean Cmax was up to 4 times higher and mean AUC was up to 12 times higher compared to extensive metabolizers.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Administration advice:

-May be taken without regard to food; however, some patients may benefit from administering the dose prior to a meal if post-meal symptoms do not resolve under post-fed conditions.
-Should be swallow whole
-Should not be chewed

For patients who have difficulty swallowing capsules, follow the instructions below for administration:
Administration with Applesauce:
-Place one tablespoon of applesauce into a clean container.
-Open the capsule and sprinkle intact granules on applesauce.
-Swallow applesauce and granules immediately. Do not chew granules. Do not save the applesauce and granules for later use.

Administration with Water in an Oral Syringe:
-Open the capsule and empty the granules into a clean container with 20 mL of water.
-Withdraw the entire mixture into a syringe.
-Gently swirl the syringe in order to keep granules from settling.
-Administer the mixture immediately into the mouth. Do not save the water and granule mixture for later use.
-Refill the syringe with 10 mL of water, swirl gently, and administer.
-Refill the syringe again with 10 mL of water, swirl gently, and administer.

Administration with Water via a Nasogastric Tube (greater than or equal to a 16 French):
-Open the capsule and empty the granules into a clean container with 20 mL of water.
-Withdraw the entire mixture into a catheter-tip syringe.
-Swirl the syringe gently in order to keep the granules from settling, and immediately inject the mixture through the nasogastric tube into the stomach. Do not save the water and granule mixture for later use.
-Refill the syringe with 10 mL of water, swirl gently, and flush the tube.
-Refill the syringe again with 10 mL of water, swirl gently, and administer.

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