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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Erosive Esophagitis
Healing of Erosive Esophagitis (EE):
-Initial dose: 60 mg orally once a day for up to 8 weeks
-Maintenance dose: 30 mg orally once a day for up to 6 months
Relief of Heartburn: 30 mg orally once a day for up to 6 months
Uses: Healing of all grades of EE, maintenance of healed EE, and relief of heartburn
Usual Adult Dose for Gastroesophageal Reflux Disease
Symptomatic Non-Erosive Gastroesophageal Reflux Disease (GERD):
-30 mg orally once a day for 4 weeks
Renal Dose Adjustments
No adjustment recommended
Liver Dose Adjustments
Mild hepatic impairment (Child-Pugh A): No adjustment recommended.
Moderate hepatic impairment (Child-Pugh B): Maximum daily dose should not exceed 30 mg.
Severe hepatic impairment (Child-Pugh C): No studies have been conducted.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
-This drug can be taken without regard to food.
-This drug should not be chewed; it should be swallowed whole.
-For patients that have difficulty swallowing capsules, the contents of a capsule can be sprinkled on applesauce, or it can be dissolved in 20 mL of water and withdraw the entire mixture into an oral syringe. Administer immediately into the mouth. Refill the syringe with 10 mL of water, swirl gently and administer. Repeat this step one more time.
Administration with water via a nasogastric tube:
-Open the capsule and dissolve the content in 20 mL of water.
-Withdraw the entire mixture into a catheter-tip syringe, swirl the syringe gently in order to keep the granules from settling, and immediately inject the mixture through the nasogastric tube into the stomach.
-Do not save the water and granule mixture for later use.
-Refill the syringe with 10 mL of water, swirl gently, and flush the tube.
-Refill the syringe again with 10 mL of water, swirl gently, and administer.
-Report immediately and seek care if diarrhea does not improve. This may be a sign of Clostridium difficile associated diarrhea.
-Report immediately and seek care for any cardiovascular or neurological symptoms including palpitations, dizziness, seizures, and tetany as these may be signs of hypomagnesemia.