Dexlansoprazole Dosage

This dosage information may not include all the information needed to use Dexlansoprazole safely and effectively. See additional information for Dexlansoprazole.

The information at is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Erosive Esophagitis

Initial dose: 60 mg orally once a day for up to 8 weeks

Maintenance dose: 30 mg orally once a day for up to 6 months

Usual Adult Dose for Gastroesophageal Reflux Disease

For treatment of heartburn associated with non-erosive GERD: 30 mg once a day for 4 weeks

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Mild hepatic impairment (Child-Pugh A): No adjustment recommended

Moderate hepatic impairment (Child-Pugh B): Maximum daily dose should not exceed 30 mg.

Severe hepatic impairment (Child-Pugh C): No studies have been conducted


Systemic exposure of dexlansoprazole is generally higher in intermediate and poor metabolizers of the polymorphic liver enzyme CYP450 2C19. In subjects who received a single dose of dexlansoprazole 30 mg or 60 mg, mean dexlansoprazole Cmax and AUC values were up to 2 times higher in intermediate compared to extensive metabolizers; in poor metabolizers, mean Cmax was up to 4 times higher and mean AUC was up to 12 times higher compared to extensive metabolizers.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).


Data not available

Other Comments

Dexlansoprazole may be taken without regard to food; however, some patients may benefit from administering the dose prior to a meal if post-meal symptoms do not resolve under post-fed conditions.

Dexlansoprazole should be swallowed whole; alternatively, the capsules can be opened and sprinkled on one teaspoonful of applesauce and immediately swallowed.