Generic Name: rabeprazole (ra BEP ra zole)
Brand Names: Aciphex

What is Aciphex?

Aciphex (rabeprazole) belongs to a group of drugs called proton pump inhibitors. Aciphex decreases the amount of acid produced in the stomach.

Aciphex is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. It is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

Aciphex may also be given with an antibiotic to prevent gastric ulcer caused by infection with helicobacter pylori (H. pylori).

Aciphex is not for immediate relief of heartburn symptoms.

Aciphex may also be used for other purposes not listed in this medication guide.

Important information

You should not use Aciphex if you are allergic to rabeprazole or to similar medicines such as lansoprazole (Prevacid), esomeprazole (Nexium), omeprazole (Prilosec, Zegerid), or pantoprazole (Protonix). Rabeprazole is not for immediate relief of heartburn symptoms.

Slideshow: Upcoming First Time Generic Approvals in 2013

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.

Some conditions are treated with a combination of Aciphex and antibiotics. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

Take Aciphex for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

Before taking this medicine

You should not use Aciphex if you are allergic to rabeprazole or to similar medicines such as lansoprazole (Prevacid), esomeprazole (Nexium), omeprazole (Prilosec, Zegerid), or pantoprazole (Protonix).

To make sure you can safely take Aciphex, tell your doctor if you have severe liver disease or low magnesium levels in your blood.

Some conditions are treated with a combination of Aciphex and antibiotics. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

Taking a proton pump inhibitor such as Aciphex may increase your risk of bone fracture in the hip, wrist, or spine. This effect has occurred mostly in people who have taken the medication long term or at high doses, and in those who are age 50 and older. It is not clear whether Aciphex is the actual cause of an increased risk of fracture. Before you take Aciphex tell your doctor if you have osteoporosis or osteopenia (low bone mineral density).

FDA pregnancy category B. Aciphex is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether rabeprazole passes into breast milk or if it could harm a nursing baby. Do not use Aciphex without telling your doctor if you are breast-feeding a baby.

See also: Pregnancy and breastfeeding warnings (in more detail)

How should I take Aciphex?

Take Aciphex exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Aciphex is usually given for 4 to 8 weeks only. Your doctor may recommend a second course of treatment if you need additional healing time.

When treating H. pylori infection, Aciphex may be needed for only 7 days. Follow your doctor's instructions.

Take this medicine with a full glass (8 ounces) of water.

Aciphex may be taken with or without food.

Do not crush, break, or chew a Aciphex tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time. Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Call your doctor if your symptoms do not improve or if they get worse while you are taking Aciphex.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

This medication can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking Aciphex and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Aciphex side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Aciphex: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Aciphex and call your doctor at once if you have symptoms of low magnesium such as:

  • dizziness, confusion;

  • fast or uneven heart rate;

  • jerking muscle movements;

  • feeling jittery;

  • diarrhea that is watery or bloody;

  • muscle cramps, muscle weakness or limp feeling;

  • cough or choking feeling; or

  • seizure (convulsions).

Less serious Aciphex side effects may include:

  • headache;

  • upset stomach or mild diarrhea;

  • insomnia or nervousness; or

  • a rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Aciphex?

Tell your doctor about all other medicines you use, especially:

  • atazanavir (Reyataz);

  • a blood thinner such as warfarin (Coumadin, Jantoven);

  • digoxin (digitalis, Lanoxin);

  • a diuretic (water pill);

  • ketoconazole (Nizoral);

  • methotrexate (Rheumatrex, Trexall); or

  • cyclosporine (Gengraf, Sandimmune, Neoral).

This list is not complete and other drugs may interact with Aciphex. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Aciphex.
  • Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Copyright 1996-2014 Cerner Multum, Inc. Version: 8.03. Revision Date: 2013-11-13, 11:45:46 AM.

Hide
(web1)