Amlodipine / Benazepril Dosage
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: 1 capsule (amlodipine 2.5 mg-benazepril 10 mg) orally once a day.
Maintenance dose: May increase every week up to a dose of amlodipine 10 mg-benazepril 40 mg orally once a day.
Renal Dose Adjustments
In patients with more severe renal impairment (CrCl less than or equal to 30 mL/min), the recommended initial dose of benazepril is 5 mg. Amlodipine-benazepril is not recommended in these patients.
Liver Dose Adjustments
In patients with hepatic impairment, the recommended initial dose of amlodipine, as monotherapy or as a component of combination therapy, is 2.5 mg.
Coadministration of multiple doses of 10 mg of amlodipine with 80 mg simvastatin resulted in a 77% increase in exposure to simvastatin compared to simvastatin alone. The dose of simvastatin should be limited in patients on amlodipine to 20 mg daily.
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Amlodipine is not removed by hemo- or peritoneal dialysis. Benazepril is only slightly dialyzable.
More about amlodipine/benazepril
- Other brands: Lotrel