Trandolapril

Trandolapril is used for:

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Treatment of high blood pressure. It is also used to prevent hospitalization and improve survival after a heart attack in certain patients. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.

Trandolapril is an angiotensin-converting enzyme (ACE) inhibitor. It works by helping to relax blood vessels. This helps to lower blood pressure.

Do NOT use Trandolapril if:

• you are allergic to any ingredient in Trandolapril or to any other ACE inhibitor (eg, enalapril)
• you have ever had an allergic reaction (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue) to any other ACE inhibitor (eg, captopril, lisinopril)
• you are pregnant

Contact your doctor or health care provider right away if any of these apply to you.

Before using Trandolapril :

Some medical conditions may interact with Trandolapril . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines or other substances
• if you have bone marrow depression, heart problems, high blood potassium levels, low blood sodium levels, kidney disease or transplant, an autoimmune disease, lupus, or thickening of the skin, or if you are having an allergic reaction
• if you are on a sodium-restricted diet
• if you have low blood volume, diarrhea, vomiting, or are undergoing dialysis

Some MEDICINES MAY INTERACT with Trandolapril . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Indomethacin, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen), or salicylates (eg, aspirin) because they may decrease Trandolapril 's effectiveness
• Indomethacin, loop diuretics (eg, furosemide), NSAIDs (eg, ibuprofen, naproxen), or thiazide-type diuretics (eg, hydrochlorothiazide) because they may increase the risk of Trandolapril 's side effects
• Indomethacin, lithium, loop diuretics (eg, furosemide), NSAIDs (eg, ibuprofen, naproxen), potassium preparations (eg, potassium chloride), potassium-sparing diuretics (eg, spironolactone), sulfonylureas (eg, glipizide), thiazide-type diuretics (eg, hydrochlorothiazide), or trimethoprim because the risk of their side effects may be increased by Trandolapril
• Loop diuretics (eg, furosemide) or thiopurines (eg, azathioprine) because their effectiveness may be decreased by Trandolapril

This may not be a complete list of all interactions that may occur. Ask your health care provider if Trandolapril may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Trandolapril :

Use Trandolapril as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Trandolapril by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Taking Trandolapril at the same time each day will help you remember to take it.
• Do not take an antacid within 1 hour before or 2 hours after you take Trandolapril .
• Do not take dextran sulfate within 2 hours of Trandolapril .
• Drinking extra fluids while you are taking Trandolapril is recommended. Check with your doctor for instructions. Not drinking enough fluids, or excessive sweating, diarrhea, or vomiting can lead to lightheadedness or fainting.
• If you miss a dose of Trandolapril , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Trandolapril .

Important safety information:

• Trandolapril may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Take Trandolapril with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking Trandolapril ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. If lightheadedness occurs, especially during the first few days of treatment, contact your health care provider.
• Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
• Tell your doctor or dentist that you take Trandolapril before you receive any medical or dental care, emergency care, or surgery.
• Check with your doctor before you use a salt substitute or a product that has potassium in it.
• Trandolapril may not work as well in black patients. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse.
• Lab tests may be performed while you take Trandolapril . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Trandolapril should not be used in CHILDREN younger than 6 months old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Do not take Trandolapril after the third month of pregnancy. It may cause injury or death to the fetus. If you become pregnant, contact your doctor right away. Trandolapril is found in breast milk. Do not breast-feed while taking Trandolapril .

Possible side effects of Trandolapril :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; fatigue; headache; indigestion; lightheadedness when sitting up or standing; muscle aches; nausea; persistent, dry cough; tiredness; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fever; hoarseness; irregular or slow heartbeat; shortness of breath; sore throat; unusual stomach pain; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include dizziness; lightheadedness, especially upon standing; weakness.

Store Trandolapril at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Trandolapril out of the reach of children and away from pets.

General information:

• If you have any questions about Trandolapril , please talk with your doctor, pharmacist, or other health care provider.
• Trandolapril is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Trandolapril . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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