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Indomethacin

Pronunciation

Generic Name: indomethacin (IN-doe-METH-a-sin)
Brand Name: Indocin IV

Indomethacin is used for:

Treating patent ductus arteriosus (PDA) in certain premature infants.

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID). It is thought to work by blocking the action of a certain chemical in the body called prostaglandin.

Do NOT use indomethacin if:

  • you are allergic to any ingredient in indomethacin
  • you have an untreated infection, active bleeding (especially in the brain, stomach, or intestinal bleeding), low blood platelets, blood clotting problems, certain severe bowel problems (eg, necrotizing enterocolitis), severe kidney problems, or certain types of congenital heart disease
  • you are taking probenecid

Contact your doctor or health care provider right away if any of these apply to you.

Before using indomethacin:

Some medical conditions may interact with indomethacin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines (eg, NSAIDs) foods, or other substances
  • if you have stomach or intestinal lesions, ulcers, or bleeding; or blood or bleeding problems
  • if you have congestive heart failure; kidney or liver problems; urinary problems; high blood pressure in the lungs; mouth sores; seizures; or low blood sodium levels
  • if you have an infection

Some MEDICINES MAY INTERACT with indomethacin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin), heparin, or salicylates (eg, aspirin) because the risk of bleeding may be increased
  • Angiotensin converting enzyme (ACE) inhibitors (eg, captopril), angiotensin receptor blockers (eg, losartan), cyclosporine, or triamterene because the risk of kidney problems may be increased
  • Fluoroquinolones (eg, ofloxacin) because the risk of seizures may be increased
  • Cyclophosphamide or probenecid because they may increase the risk of indomethacin's side effects
  • Aminoglycosides (eg, amikacin, gentamicin), digitalis, digoxin, lithium, or methotrexate because the risk of their side effects may be increased by indomethacin
  • Beta-blockers (eg, metoprolol) or diuretics (eg, furosemide) because their effectiveness may be decreased by indomethacin

This may not be a complete list of all interactions that may occur. Ask your health care provider if indomethacin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use indomethacin:

Use indomethacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Indomethacin is usually given as an injection at a doctor's office, hospital, or clinic.
  • If you miss a dose of indomethacin, contact the doctor right away.

Ask your health care provider any questions you may have about the proper use of indomethacin.

Important safety information:

  • Indomethacin may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Lab tests, including liver function, kidney function, lung function, blood counts, and blood electrolytes, may be performed while you use indomethacin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: Indomethacin is not approved for use in adults.

Possible side effects of indomethacin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Redness, pain, or oozing at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in vomit, stool, or urine; dark, tarry stools; decreased urination; slow heartbeat; unusual bruising or bleeding; unusual weight gain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of indomethacin:

Indomethacin is usually handled and stored by a health care provider. Keep indomethacin out of the reach of children and away from pets.

General information:

  • If you have any questions about indomethacin, please talk with your doctor, pharmacist, or other health care provider
  • Indomethacin is to be used only by the patient for whom it is prescribed. Do not share it with other people
  • If your symptoms do not improve or if they become worse, check with your doctor
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take indomethacin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about indomethacin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to indomethacin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using indomethacin.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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