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Caldolor Injection

Generic Name: ibuprofen injection (EYE bue proe fen)
Brand Names: Caldolor

What is Caldolor?

Caldolor (ibuprofen) is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Caldolor injection is used to reduce fever and treat pain.

Caldolor may also be used for purposes not listed in this medication guide.

Important information

You should not receive Caldolor just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Caldolor may increase your risk of heart attack or stroke. Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

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Caldolor may also cause stomach or intestinal bleeding. Call your doctor at once if you have bloody or tarry stools, or if you cough up blood or vomit that looks like coffee grounds.

Before taking this medicine

Caldolor may increase your risk of heart attack or stroke, especially if you use it long term or have heart disease. You should not receive this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Caldolor may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are receiving ibuprofen injection.

You should not use Caldolor if you are allergic to ibuprofen (Advil, Motrin), aspirin or other NSAIDs.

To make sure Caldolor is safe for you, tell your doctor if you have:

  • a history of heart attack, stroke, or blood clot;

  • heart disease, high blood pressure;

  • a history of stomach ulcer or bleeding;

  • liver or kidney disease;

  • a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis;

  • a bleeding or blood clotting disorder; or

  • asthma, or a history of severe allergic reaction to aspirin, especially aspirin triad syndrome.

FDA pregnancy category D. Using Caldolor during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while receiving Caldolor.

See also: Pregnancy and breastfeeding warnings (in more detail)

It is not known whether ibuprofen injection passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How is Caldolor injection given?

Caldolor is injected into a vein through an IV. A healthcare provider will give you this injection.

Drink plenty of liquids while you are receiving Caldolor injection.

What happens if I miss a dose?

Because you will receive Caldolor injection in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid?

Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to Caldolor. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains naproxen, aspirin, ibuprofen, ketoprofen, or naproxen.

Caldolor side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Caldolor: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have:

  • chest pain, shortness of breath, sudden numbness or weakness, severe headache, slurred speech, problems with vision or balance;

  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • swelling or rapid weight gain;

  • little or no urinating;

  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;

  • bruising, severe tingling, numbness, pain, muscle weakness;

  • severe headache, neck stiffness, chills, increased sensitivity to light, and/or seizure (convulsions); or

  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common Caldolor side effects may include:

  • nausea, vomiting, gas;

  • headache; or

  • dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Caldolor?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Caldolor injection, especially:

  • lithium;

  • methotrexate;

  • an ACE inhibitor--benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril;

  • a blood thinner such as warfarin, Coumadin; or

  • a diuretic or "water pill."

This list is not complete. Other drugs may interact with Caldolor injection, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Caldolor.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Caldolor only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2015 Cerner Multum, Inc. Version: 1.03. Revision Date: 2013-11-27, 5:08:33 PM.