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Caldolor Injection

Generic Name: ibuprofen injection (EYE bue proe fen)
Brand Names: Caldolor

What is Caldolor?

Caldolor (ibuprofen) is a nonsteroidal anti-inflammatory drug (NSAID) injection. Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Caldolor injection is used to reduce fever and treat pain.

Caldolor may also be used for purposes not listed in this medication guide.

Important information

You should not receive Caldolor just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

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Caldolor can increase your risk of fatal heart attack or stroke, especially if you use it long term or use high doses, or if you have heart disease.

Before taking this medicine

Caldolor can increase your risk of fatal heart attack or stroke, especially if you use it long term or use high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while using this medicine.

You should not receive this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Caldolor may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Caldolor, especially in older adults.

You should not use Caldolor if you are allergic to ibuprofen, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

To make sure Caldolor is safe for you, tell your doctor if you have:

  • heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;

  • a history of heart attack, stroke, or blood clot;

  • a history of stomach ulcers or bleeding;

  • asthma;

  • liver or kidney disease;

  • fluid retention; or

  • a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, or lupus.

Using Caldolor during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while receiving Caldolor.

It is not known whether ibuprofen injection passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How is Caldolor injection given?

Caldolor injection is injected into a vein through an IV. A healthcare provider will give you this injection.

Drink plenty of liquids while you are receiving Caldolor injection.

What happens if I miss a dose?

Because you will receive Caldolor injection in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving Caldolor?

Avoid taking aspirin while you are receiving Caldolor.

Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to ibuprofen. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.

Caldolor side effects

Get emergency medical help if you have signs of an allergic reaction to Caldolor: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Tell your caregivers at once if you have:

  • changes in your vision;

  • shortness of breath (even with mild exertion);

  • swelling or rapid weight gain;

  • the first sign of any skin rash, no matter how mild;

  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • liver problems--nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • kidney problems--little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;

  • low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or

  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common Caldolor side effects may include:

  • nausea, vomiting, gas;

  • headache; or

  • dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Caldolor?

Tell your doctor if you are taking aspirin to prevent stroke or heart attack. Caldolor can make aspirin less effective in protecting your heart and blood vessels.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Caldolor injection, especially:

  • lithium;

  • methotrexate;

  • a blood thinner (warfarin, Coumadin, Jantoven);

  • heart or blood pressure medication, including a diuretic or "water pill"; or

  • steroid medicine (such as prednisone).

This list is not complete. Other drugs may interact with ibuprofen, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Caldolor.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Caldolor only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2015 Cerner Multum, Inc. Version: 2.01. Revision Date: 2015-09-09, 3:00:19 PM.