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Ibuprofen Pregnancy and Breastfeeding Warnings

Ibuprofen is also known as: Actiprofen, Addaprin, Advil, Advil Infant's Concentrated Drops, Advil Liqui-Gels, Advil Migraine, Caldolor, Children's Motrin, Childrens Ibuprofen Berry, Genpril, Haltran, IBU, IBU-200, Ibu-Tab, Ibuprofen PMR, Menadol, Midol IB, Midol Maximum Strength Cramp Formula, Motrin, Motrin Childrens, Motrin IB, NeoProfen, Nuprin, Rufen, Saleto-200

Ibuprofen Pregnancy Warnings

Ibuprofen has been assigned by the FDA to pregnancy category C prior to 30 weeks gestation and pregnancy category D at greater than or equal to 30 weeks gestation. Animal studies have failed to reveal evidence of developmental abnormalities. There are no controlled data in human pregnancy. While there are no literature reports linking the use of ibuprofen in pregnancy with birth defects, use of ibuprofen at greater than or equal to 30 weeks gestation may cause premature closure of the ductus arteriosus and prolong labor and delivery. Ibuprofen should only be given during pregnancy when benefit outweighs risk and should be avoided on or after 30 weeks gestation.

In rat studies with NSAIDs, as with other drugs known to inhibit prostaglandin synthesis, an increased incidence of dystocia, delayed parturition, and decreased pup survival occurred. The effects of ibuprofen on labor and delivery in pregnant women are unknown.

See references

Ibuprofen Breastfeeding Warnings

There are no data on the excretion of ibuprofen into human milk. The effects in the nursing infant are unknown. The manufacturer recommends that a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. Koren G, Pastuszak A, Ito S "Drugs in pregnancy." N Engl J Med 338 (1998): 1128-37
  2. "Product Information. Caldolor (ibuprofen)." Cumberland Pharmaceuticals Inc, Nashville, TN.
  3. Ostensen M "Optimisation of antirheumatic drug treatment in pregnancy." Clin Pharmacokinet 27 (1994): 486-503
  4. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
  5. Barry WS, Meinzinger MM, Howse CR "Ibuprofen overdose and exposure in Utero: results from a postmarketing voluntary reporting system." Am J Med 77 (1984): 35-9

References for breastfeeding information

  1. Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
  2. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
  3. Townsend RJ, Benedetti TJ, Erickson SH, Cengiz C, Gillespie Wr, Gschwend J, Albert KS "Excretion of ibuprofen into breast milk." Am J Obstet Gynecol 149 (1984): 184-6
  4. "Product Information. Caldolor (ibuprofen)." Cumberland Pharmaceuticals Inc, Nashville, TN.
  5. Weibert RT, Townsend RJ, Kaiser DG, Naylor AJ "Lack of ibuprofen secretion into human milk." Clin Pharm 1 (1982): 457-8

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