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Zoster vaccine, recombinant Side Effects

Medically reviewed by Last updated on Oct 31, 2023.

Applies to zoster vaccine, recombinant: intramuscular suspension.

Serious side effects

Along with its needed effects, zoster vaccine, recombinant may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking zoster vaccine, recombinant:


Incidence not known

Other side effects

Some side effects of zoster vaccine, recombinant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to zoster vaccine, recombinant: intramuscular powder for injection.


Very common (10% or more): Local pain (88.4%), local redness (38.7%)

Common (1% to 10%): Injection site pruritus[Ref]


Very common (10% or more): Fatigue (57%), shivering (35.8%), fever (27.8%)

Common (1% to 10%): Malaise

Uncommon (0.1% to 1%): Death[Ref]

Deaths were reported for 0.8% of patients in the treatment group during the first year after vaccination versus 0.9% of placebo patients. Causes of death were consistent with those generally reported in adult and elderly populations.[Ref]

Nervous system

Very common (10% or more): Headache (50.6%)

Common (1% to 10%): Dizziness[Ref]


Very common (10% or more): Gastrointestinal symptoms (24.3%)

Common (1% to 10%): Nausea[Ref]


Uncommon (0.1% to 1%): Gout (including gouty arthritis)[Ref]


Rare (less than 0.1%): Optic ischemic neuropathy[Ref]


Very rare (less than 0.01%): Lymphadenitis[Ref]


Very common (10% or more): Myalgia (56.9%)

Common (1% to 10%): Chills, arthralgia[Ref]


1. Product Information. Shingrix (zoster vaccine, inactivated). GlaxoSmithKline. 2017.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.