Zinecard Side Effects

Generic name: dexrazoxane

Medically reviewed by Drugs.com. Last updated on Feb 14, 2025.

Note: This document provides detailed information about Zinecard.

Applies to dexrazoxane: intravenous powder for solution Side Effects associated with dexrazoxane. Some dosage forms listed on this page may not apply specifically to the brand name Zinecard.

Applies to dexrazoxane: intravenous powder for solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests are needed to check for unwanted effects.

Receiving this medicine while you are pregnant can harm your unborn baby. It may also cause birth defects if the father is receiving it when his sexual partner becomes pregnant. Female patients should use an effective form of birth control during treatment with this medicine and for at least 6 months after the last dose. Male patients who have female partners should use effective birth control during treatment and for at least 3 months after the last dose. If you think you have become pregnant while receiving this medicine, tell your doctor right away.

If you plan to have children, talk with your doctor before using this medicine. Some men receiving this medicine have become infertile (unable to have children).

Dexrazoxane can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

• If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
• Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in urine or stools, or pinpoint red spots on your skin.
• Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
• Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
• Be careful not to cut yourself when you are using sharp objects, such as a safety razor or fingernail or toenail cutters.
• Avoid contact sports or other situations where bruising or injury could occur.

If you are also taking doxorubicin: This medicine may not protect your heart completely. It is important to tell your doctor if you have any symptoms of heart problems, including trouble breathing, chest pain, lightheadedness, dizziness, or a fast or uneven heartbeat.

This medicine may increase your risk for certain cancers, including acute myeloid leukemia and myelodysplastic syndrome. Talk to your doctor if you have questions or concerns.

This medicine may cause a serious allergic reaction, including anaphylaxis and angioedema. These can be life-threatening and require immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing or swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Zinecard

Along with its needed effects, dexrazoxane (the active ingredient contained in Zinecard) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking dexrazoxane:

Other side effects of Zinecard

Some side effects of dexrazoxane may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to dexrazoxane: intravenous powder for injection.

General adverse events

Adverse events reported are from clinical trials where patients were also receiving chemotherapy while on this drug, and reflect the combination of this drug, already administered chemotherapy, and the patients underlying condition.^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (77%), vomiting (59%), stomatitis (34%), diarrhea (21%)
• Common (1% to 10%): Abdominal pain, constipation, esophagitis, dysphagia^[Ref]

Hematologic

• Very common (10% or more): Decreased white blood count (73%), decreased neutrophils (61%) decreased hemoglobin (43%), decreased platelets (23%)
• Common (1% to 10%): Anemia^[Ref]

Dermatologic

• Very common (10% or more): Alopecia (up to 100%)
• Common (1% to 10%): Streaking/erythema, urticaria^[Ref]

Local

• Very common (10% or more): Injection site pain/discomfort (16%)
• Common (1% to 10%): Injection site phlebitis, extravasation^[Ref]

Hepatic

• Very common (10% or more): Increased AST (28%), increased ALT (22%)
• Common (1% to 10%): Increased LDH, increased alkaline phosphatase^[Ref]

Nervous system

• Very common (10% or more): Neurotoxicity (17%), dizziness (11%)
• Common (1% to 10%): Headache^[Ref]

Metabolic

• Very common (10% or more): Anorexia (42%)
• Common (1% to 10%): Increased calcium total, decreased sodium^[Ref]

Immunologic

• Very common (10% or more): Infection (23%), sepsis (17%), postoperative infection (16%)
• Common (1% to 10%): Pneumonia^[Ref]

Other

• Very common (10% or more): Fever (34%), fatigue (61%), pain on injection (13%), edema peripheral (10%)^[Ref]

Renal

• Very common (10% or more): Increased creatinine (14%)^[Ref]

Cardiovascular

• Common (1% to 10%): Cardiac disorders, phlebitis, hemorrhage^[Ref]

Psychiatric

• Common (1% to 10%): Depression, insomnia^[Ref]

Respiratory

• Common (1% to 10%): Dyspnea, cough^[Ref]

See also:

Further information

Zinecard side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer