Yohimbine Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 18, 2024.

Applies to yohimbine: compounding powder, oral tablet.

If you experience any of the following serious side effects, stop taking yohimbine and seek emergency medical attention:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• a very irregular or fast heartbeat; or

• confusion or unusual behavior.

Other, less serious side effects are more likely to occur. Continue to take yohimbine and talk to your doctor if you experience

• dizziness;

• anxiety, irritability, or nervousness;

• tremor (shaking);

• headache; or

• skin flushing.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to yohimbine: compounding powder, oral tablet.

General adverse events

General side effects have included headache and increase in sweating.^[Ref]

Cardiovascular

Cardiovascular side effects have included elevation in blood pressure and increase in heart rate.^[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea and vomiting, commonly reported after parenteral administration of yohimbine.^[Ref]

Psychiatric

Psychiatric side effects have included irritability and generalized anxiety.^[Ref]

Nervous system

Nervous system side effects have included excitation, increased motor activity, tremor, and dizziness.^[Ref]

Dermatologic

Dermatologic side effects have included skin flushing reported with oral administration.^[Ref]

Other

A severe case of Raynaud's phenomenon has been reported in a 65-year-old man diagnosed with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia). Painful episodes which affected all toes and fingers and his penis lasted 10 to 15 minutes and were relieved with heat. Symptoms resolved slowly over time upon discontinuation of yohimbine. Upon rechallenge with yohimbine, the patient developed more severe Raynaud's phenomenon.^[Ref]

See also:

Further information

Yohimbine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer