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Yohimbe Side Effects

Generic name: yohimbine

Medically reviewed by Last updated on Apr 25, 2023.

Note: This document contains side effect information about yohimbine. Some dosage forms listed on this page may not apply to the brand name Yohimbe.

Applies to yohimbine: compounding powder, oral tablet.

Nervous system

Nervous system side effects have included excitation, increased motor activity, tremor, and dizziness.[Ref]


Cardiovascular side effects have included elevation in blood pressure and increase in heart rate.[Ref]


Gastrointestinal side effects have included nausea and vomiting, commonly reported after parenteral administration of yohimbine (the active ingredient contained in Yohimbe) [Ref]


Psychiatric side effects have included irritability and generalized anxiety.[Ref]


General side effects have included headache and increase in sweating.[Ref]


Dermatologic side effects have included skin flushing reported with oral administration.[Ref]


A severe case of Raynaud's phenomenon has been reported in a 65-year-old man diagnosed with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia). Painful episodes which affected all toes and fingers and his penis lasted 10 to 15 minutes and were relieved with heat. Symptoms resolved slowly over time upon discontinuation of yohimbine (the active ingredient contained in Yohimbe) Upon rechallenge with yohimbine, the patient developed more severe Raynaud's phenomenon.[Ref]


1. Product Information. Yocon (yohimbine). Glenwood Inc. 2001.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.