Xigris Side Effects
Generic name: drotrecogin alfa
Note: This document contains side effect information about drotrecogin alfa. Some of the dosage forms listed on this page may not apply to the brand name Xigris.
Applies to drotrecogin alfa: intravenous powder for injection
The most common side effect associated with drotrecogin alfa (the active ingredient contained in Xigris) has been bleeding.[Ref]
Hematologic side effects have most commonly included bleeding (25% vs 18% with placebo). The majority of events were ecchymoses or gastrointestinal tract bleeding. Serious bleeding has been reported in 3.5% of patients (vs 2% with placebo) and included intracranial hemorrhage, life threatening hemorrhage, and any event requiring 3 or more units of packed red blood cells per days for 2 consecutive days.[Ref]
Serious bleeding events have been reported at the following sites: Gastrointestinal, intra-abdominal, intrathoracic, retroperitoneal, intracranial, genitourinary, skin or soft tissues.[Ref]
More about Xigris (drotrecogin alfa)
- During Pregnancy
- Dosage Information
- Drug Interactions
- 1 Review
- Drug class: miscellaneous coagulation modifiers
Related treatment guides
1. Bernard GR, Vincent JL, Laterre PF, et al. "Efficacy and safety of recombinant human activated protein C for severe sepsis." N Engl J Med 344 (2001): 699-709
2. "Product Information. Xigris (drotrecogin alfa)." Lilly, Eli and Company, Indianapolis, IN.
Some side effects may not be reported. You may report them to the FDA.