Xigris Side Effects

Generic Name: drotrecogin alfa

Note: This document contains side effect information about drotrecogin alfa. Some of the dosage forms listed on this page may not apply to the brand name Xigris.

Applies to drotrecogin alfa: intravenous powder for injection

General

The most common side effect associated with drotrecogin alfa (the active ingredient contained in Xigris) has been bleeding.^[Ref]

Hematologic

Hematologic side effects have most commonly included bleeding (25% vs 18% with placebo). The majority of events were ecchymoses or gastrointestinal tract bleeding. Serious bleeding has been reported in 3.5% of patients (vs 2% with placebo) and included intracranial hemorrhage, life threatening hemorrhage, and any event requiring 3 or more units of packed red blood cells per days for 2 consecutive days.^[Ref]

Serious bleeding events have been reported at the following sites: Gastrointestinal, intra-abdominal, intrathoracic, retroperitoneal, intracranial, genitourinary, skin or soft tissues.^[Ref]

Some side effects of Xigris may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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