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Xeloda Side Effects

Generic name: capecitabine

Medically reviewed by Drugs.com. Last updated on Dec 26, 2024.

Note: This document provides detailed information about Xeloda Side Effects associated with capecitabine. Some dosage forms listed on this page may not apply specifically to the brand name Xeloda.

Applies to capecitabine: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Warning: Increased Risk of Bleeding with Concomitant Use of Vitamin K Antagonists. Altered coagulation parameters and/or bleeding, including death, have been reported in patients taking capecitabine concomitantly with oral vitamin K antagonists, such as warfarin.Clinically significant increases in prothrombin time (PT) and international normalized ratio (INR) have been reported in patients who were on stable doses of a vitamin K antagonist at the time capecitabine was introduced.

These events occurred within several days and up to several months after initiating capecitabine and, in a few cases, within 1 month after stopping capecitabine.

These events occurred in patients with and without liver metastases.Monitor INR more frequently and adjust the dose of the vitamin K antagonist as appropriate.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

Your doctor may request that you have a test to determine if your blood is clotting properly, and may preform this test frequently if you are also taking a blood thinner.

Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before taking this medicine. Female patients must use effective birth control during treatment and for 6 months after your treatment ends. Male patients with partners of childbearing potential should also use effective contraception during treatment and for 3 months after the last dose. Tell your doctor right away if you think you have become pregnant.

This medicine may increase risk of bleeding when used together with a blood thinner (eg, warfarin). Check with your doctor right away if you have back pain, blood in the eyes, blood in the urine, black, tarry stools, bruising or purple areas on the skin, coughing up blood, decreased alertness, dizziness, headache, joint pain or swelling, or nosebleeds.

This medicine may cause heart problems. Check with your doctor right away if you have chest pain that may spread to your arms, jaw, back, or neck, chest tightness, decreased urine output, dilated neck veins, faintness, nausea, sweating, swelling in your hands, ankles, or feet, trouble breathing, unusual sweating, vomiting.

This medicine may cause kidney problems. Check with your doctor right away if you have agitation, coma, confusion, decreased urine output, depression, dizziness, headache, hostility, irritability, lethargy, muscle twitching, nausea, rapid weight gain, seizures, stupor, swelling of the face, ankles, or hands, or unusual tiredness or weakness.

Check with your doctor right away if any of the following symptoms occur:

If vomiting occurs less often than mentioned above, or if nausea does not cause you to eat less than usual, it is not necessary for you to stop taking the medicine or to check with your doctor (unless these effects are particularly bothersome). Also, you do not need to stop taking the medicine if diarrhea occurs less often than mentioned above or if the other side effects listed are not severe enough to interfere with eating or other daily activities. However, check with your doctor as soon as possible if they occur.

Check with your doctor right away if you have confusion, decreased urination, dizziness, dry mouth, fainting, increase in heart rate, lightheadedness, rapid breathing, sunken eyes, thirst, unusual tiredness or weakness, or wrinkled skin. These may be symptoms of dehydration.

Serious skin reactions (eg, Stevens-Johnson syndrome and toxic epidermal necrolysis) can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, cough, diarrhea, itching, joint or muscle pain, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, unusual tiredness or weakness, or fever or chills while you are using this medicine.

This medicine may cause a serious skin problem called palmar plantar erythrodysesthesia syndrome. Check with your doctor if you have a rash that does not go away or redness, pain, swelling, or blisters on the palms of your hands or soles of your feet.

While you are being treated with capecitabine (the active ingredient contained in Xeloda) and after you stop treatment with it, do not have any immunizations (vaccines) without your doctor's approval. Capecitabine may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. Some examples of live vaccines include measles, mumps, influenza (nasal flu vaccine), poliovirus (oral form), rotavirus, and rubella. Do not get close to them and do not stay in the same room with them for very long. If you have questions about this, talk to your doctor.

Capecitabine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Xeloda

Along with its needed effects, capecitabine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking capecitabine:

More common side effects

  • diarrhea
  • loss of fingerprints
  • nausea
  • numbness, pain, tingling, or other unusual sensations in the palms of the hands or bottoms of the feet
  • pain, blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet
  • pain, redness, swelling, sores, or ulcers in your mouth or on your lips
  • stomach pain
  • unusual tiredness or weakness
  • vomiting

Less common or rare side effects

  • agitation
  • back pain
  • bleeding and bruising
  • bleeding gums
  • blood in the urine or stools
  • bloody nose
  • bloody or black, tarry stools
  • blurred vision
  • burning, dry, or itching eyes
  • chest pain or tightness
  • chills
  • clumsiness or unsteadiness
  • cold
  • collapse
  • coma
  • confusion
  • constipation
  • cough or hoarseness (accompanied by fever or chills)
  • cough producing mucus
  • coughing or spitting up blood
  • dark urine
  • decreased frequency or amount of urine
  • difficulty with breathing
  • difficulty with swallowing or pain in the back of throat or chest when swallowing
  • discharge from the eyes
  • drowsiness
  • dry mouth
  • excessive tearing
  • extra heartbeats
  • eye redness, irritation, or pain
  • fainting
  • fast or irregular heartbeat
  • fever or chills
  • flu-like symptoms
  • hallucinations
  • headache, sudden and severe
  • heavier menstrual periods
  • high fever
  • hot, red skin on the feet or legs
  • inability to speak
  • increased menstrual flow or vaginal bleeding
  • increased thirst
  • irritability
  • itching in the genital or other skin areas
  • lightheadedness
  • light-colored stools
  • loss of consciousness
  • lower back or side pain (accompanied by fever or chills)
  • muscle aches, cramps, or spasms
  • nosebleeds
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination (accompanied by fever or chills)
  • painful, swollen feet or legs
  • pain, tenderness, or swelling in the upper abdominal or stomach area
  • pale skin
  • paralysis
  • pinpoint red spots on the skin
  • problems with coordination
  • prolonged bleeding from cuts
  • rapid, shallow breathing
  • red or dark brown urine
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • scaling
  • seizures
  • severe constipation
  • skin rash or itching
  • slow or irregular heartbeat
  • slurred speech
  • sneezing
  • sores, ulcers, or white spots on the lips or in the mouth
  • sore throat
  • stiff neck
  • stomach bloating, burning, or cramping
  • stuffy nose
  • swelling of the face, fingers, feet, or lower legs
  • swelling of the lymph nodes
  • swollen glands
  • temporary blindness
  • trouble with speaking
  • trouble breathing
  • unexplained nosebleeds
  • unusual bleeding or bruising
  • unusual lump or swelling in the chest
  • unusual tiredness or weakness
  • vomiting blood or material that looks like coffee grounds
  • weakness in the arm or leg on one side of the body, sudden and severe
  • weight gain or loss
  • white patches in the mouth or throat or on the tongue
  • white patches with diaper rash
  • yellow eyes or skin

Incidence not known

  • blistering, peeling, or loosening of the skin
  • chest discomfort or heaviness
  • dilated neck veins
  • dizziness
  • eye irritation or pain
  • irregular breathing
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • no blood pressure or pulse
  • pain or discomfort in the arms, jaw, back, or neck
  • red irritated eyes
  • red skin lesion, often with a purple center
  • stopping of heart
  • sweating
  • unconsciousness
  • weight gain

Other side effects of Xeloda

Some side effects of capecitabine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

  • burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • changes or discoloration in the fingernails or toenails
  • difficulty with moving
  • discouragement
  • headache
  • heartburn
  • increased sensitivity of the skin to sunlight
  • muscle pain
  • pain
  • pain and redness of the skin at the place of x-ray treatment
  • pain in the joints or limbs
  • red, sore eyes
  • sunken eyes
  • thirst
  • trouble sleeping
  • weakness
  • wrinkled skin

Rare side effects

  • bone pain
  • change in color of treated skin
  • difficulty with walking
  • discouragement
  • feeling of constant movement of self or surroundings
  • feeling sad or empty
  • full or bloated feeling or pressure in the stomach
  • general feeling of discomfort or illness
  • hot flushes
  • impaired balance
  • increased sweating
  • joint pain
  • lack of appetite
  • loss of interest or pleasure
  • muscle weakness
  • noisy breathing
  • pain in the rectum
  • pain, swelling, or redness in the joints
  • passing less gas
  • rough, scratchy sound to voice
  • runny nose
  • sensation of spinning
  • shakiness in the legs, arms, hands, or feet
  • shivering
  • sores on the skin
  • swelling of the stomach area
  • tremor or shaking of the hands or feet
  • trouble concentrating
  • voice changes

For healthcare professionals

Applies to capecitabine: oral tablet.

General adverse events

The most commonly reported adverse reactions included gastrointestinal disorders (especially diarrhea, nausea, vomiting, abdominal pain, stomatitis), palmar-plantar erythrodysesthesia (hand-foot syndrome) and other skin disorders, hematologic abnormalities, hyperbilirubinemia, and metabolic alterations.

Reported adverse reactions are compiled from use of this drug as monotherapy or in combination with different chemotherapy regimens in multiple indications. The safety profiles across indications and as monotherapy or in combination are comparable.[Ref]

Cardiovascular

Dermatologic

Gastrointestinal

Genitourinary

Hematologic

Hepatic

Hypersensitivity

Metabolic

Musculoskeletal

Nervous system

Ocular

Oncologic

Other

Psychiatric

Renal

Respiratory

See also:

References

1. (2022) "Product Information. Xeloda (capecitabine)." Genentech

2. (2022) "Product Information. Xelabine (capecitabine)." Aspen Pharma Pty Ltd

3. (2022) "Product Information. Capecitabine (Sandoz) (capecitabine)." Sandoz Pty Ltd

4. (2022) "Product Information. Capecitabine (DRLA) (capecitabine)." Dr Reddy's Laboratories Australia Pty Ltd

5. (2022) "Product Information. Capecitabine (capecitabine)." Amarox Ltd

6. (2021) "Product Information. Capecitabine (capecitabine)." Glenmark Pharmaceuticals Europe Ltd

7. (2023) "Product Information. Capecitabine (capecitabine)." Dr Reddy's Laboratories (UK) Ltd

Frequently asked questions

Further information

Xeloda side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.