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Voclosporin Side Effects

Medically reviewed by Last updated on Aug 19, 2023.

Applies to voclosporin: oral capsule liquid filled.


Oral route (Capsule)

Warning: Malignancies and Serious InfectionsIncreased risk for developing malignancies and serious infections with voclosporin or other immunosuppressants that may lead to hospitalization or death.

Serious side effects of Voclosporin

Along with its needed effects, voclosporin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking voclosporin:

More common

Less common

Other side effects of Voclosporin

Some side effects of voclosporin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to voclosporin: oral capsule.


Very common (10% or more): Anemia (12%)[Ref]


Frequency not reported: Cytomegalovirus chorioretinitis[Ref]


Frequency not reported: Hyperkalemia[Ref]


Very common (10% or more): Urinary tract infection (10%)

Frequency not reported: Azotemia, oliguria, proteinuria[Ref]


Frequency not reported: Cervical carcinoma, breast tumor excision, malignant lymphoma, malignant neoplasm, skin neoplasm[Ref]


Very common (10% or more): Cough (11%)

Frequency not reported: Pneumonia, bacterial and viral upper respiratory tract infection[Ref]

Nervous system

Very common (10% or more): Headache (15%)

Common (1% to 10%): Fatigue, tremor

Frequency not reported: Nervous system disorders, headache, tremor, dizziness, post herpetic neuralgia, migraine, paresthesia, hypoesthesia, seizure, tension headache, and disturbance in attention, migraine, seizure, and posterior reversible encephalopathy syndrome[Ref]


Very common (10% or more): Decrease in glomerular filtration rate (26%)

Common (1% to 10%): Acute kidney injury, renal dysfunction

Frequency not reported: Renal impairment, acute kidney injury, increased blood creatinine, renal failure


Very common (10% or more): Hypertension (19%)

Frequency not reported: QT prolongation[Ref]


Common (1% to 10%): Alopecia, hypertrichosis

Frequency not reported: Pyoderma gangrenosum[Ref]


Very common (10% or more): Diarrhea (19%)

Common (1% to 10%): Abdominal pain, decreased appetite, dyspepsia, gingivitis, mouth ulceration, upper abdominal pain

Frequency not reported: Gastroenteritis[Ref]


Frequency not reported: Herpes zoster infection, serious infections, opportunistic infection (including cytomegalovirus infection, and herpes zoster cutaneous disseminated)


The most frequently reported side effect was decreased in glomerular filtration rate.[Ref]


1. Product Information. Lupkynis (voclosporin). Aurinia Pharma. 2021.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.