Uplizna Side Effects

Generic name: inebilizumab

Medically reviewed by Drugs.com. Last updated on Aug 15, 2024.

Note: This document provides detailed information about Uplizna.

Applies to inebilizumab: intravenous solution Side Effects associated with inebilizumab. Some dosage forms listed on this page may not apply specifically to the brand name Uplizna.

Applies to inebilizumab: intravenous solution.

Precautions

It is very important that your doctor check your progress closely while you are receiving the medicine to make sure that it is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment and for at least 6 months after the last dose. If you think you have become pregnant while receiving this medicine, tell your doctor right away.

Inebilizumab-cdon may cause infusion-related reactions. These can be life-threatening and require immediate medical attention. Tell your doctor right away if you start to have a fever, chills or shaking, dizziness, trouble breathing, itching or rash, lightheadedness or fainting after receiving this medicine.

This medicine can temporarily lower the number of white blood cells and antibodies in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever, chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

This medicine may cause hepatitis B virus reactivation. Check with your doctor right away if you have any symptoms of liver problems, such as yellow skin or eyes, dark brown-colored urine, right-sided stomach pain, fever, or severe tiredness.

This medicine may increase your risk of developing a serious and rare brain infection called progressive multifocal leukoencephalopathy (PML). Check with your doctor right away if you have vision changes, loss of coordination, clumsiness, memory loss, difficulty speaking or understanding what others say, or weak legs.

You will need to have a skin test for tuberculosis before you start receiving this medicine. Tell your doctor if you or anyone in your home has ever had a positive reaction to a tuberculosis skin test.

Do not have any live vaccines (immunizations) while you are being treated with inebilizumab-cdon injection. You should have completed any needed immunizations at least 4 weeks before starting treatment with this medicine. Check with your doctor before having any vaccines.

Serious side effects of Uplizna

Along with its needed effects, inebilizumab (the active ingredient contained in Uplizna) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking inebilizumab:

Other side effects of Uplizna

Some side effects of inebilizumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to inebilizumab: intravenous solution.

General adverse events

The most commonly reported adverse events include infusion reaction, nasopharyngitis, urinary tract infection, arthralgia, back pain, and headache.

Hematologic

• Common (1% to 10%): Neutropenia
• Frequency not reported: Lymphocytopenia^[Ref]

Immunologic

• Common (1% to 10%): Anti-drug antibodies^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia , back pain^[Ref]

Genitourinary

• Very common (10% or more): Urinary tract infection (20%)

Respiratory

• Very common (10% or more): Nasopharyngitis (13%)
• Common (1% to 10%): Upper respiratory tract infection, influenza^[Ref]

Other

• Very common (10% or more): Infusion reaction (11.6%)^[Ref]

Nervous system

• Common (1% to 10%): Headache^[Ref]

See also:

Further information

Uplizna side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer