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Tusdec-HC Side Effects

Generic name: hydrocodone / phenylephrine

Note: This document contains side effect information about hydrocodone / phenylephrine. Some dosage forms listed on this page may not apply to the brand name Tusdec-HC.

Applies to hydrocodone/phenylephrine: oral liquid, oral syrup.


The most common adverse events were occasional drowsiness, dry mouth, blurred vision, dizziness, mild mental stimulation, and gastric irritation.[Ref]

Nervous system

Rare (less than 0.1%): Occasional drowsiness, dizziness, mild mental stimulation

Postmarketing reports: Convulsions[Ref]


Postmarketing reports: Breathing difficulties[Ref]


Postmarketing reports: Urinary retention, androgen deficiency[Ref]

Androgen deficiency:

-Chronic opioid use may affect the hypothalamic-pituitary-gonadal axis leading to androgen deficiency.

-Symptoms may include low libido, impotence, erectile dysfunction, amenorrhea, and infertility.

-Opioids role in androgen deficiency have not been evaluated where other factors (medical, physical, lifestyle, psychological) have been adequately controlled.

-Perform laboratory evaluation for symptoms of androgen deficiency.[Ref]


Rare (less than 0.1%): Mild mental stimulation

Postmarketing reports: Hallucinations[Ref]


Postmarketing reports: Rapid heart rate, reflex bradycardia[Ref]


Rare (less than 0.1%): Blurred vision[Ref]


Postmarketing reports: Allergic reaction[Ref]


Rare (less than 0.1%): Dry mouth, gastric irritation[Ref]

More about Tusdec-HC (hydrocodone / phenylephrine)

Related treatment guides


1. "PDR Generics." Montvale, NJ: Medical Economics (1998):

2. Cerner Multum, Inc. "Canadian Product Information." O 0 (2015):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.