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Triclabendazole Side Effects

Medically reviewed by Drugs.com. Last updated on June 2, 2020.

For the Consumer

Applies to triclabendazole: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, triclabendazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking triclabendazole:

More common

  • Dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • sensation of spinning

Less common

  • Chest pain, discomfort, or tightness
  • cough
  • difficulty breathing
  • fever
  • nausea
  • spinal pain
  • upper right abdominal pain
  • vomiting
  • yellow skin or eyes

Side effects not requiring immediate medical attention

Some side effects of triclabendazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

  • Abnormal color of urine
  • back pain
  • constipation
  • difficulty in moving
  • itching
  • joint pain
  • lack or loss of strength
  • muscle pain or stiffness

For Healthcare Professionals

Applies to triclabendazole: oral tablet

Gastrointestinal

Very common (10% or more): Abdominal pain (included upper abdominal pain, abdominal pain; up to 93%), nausea (up to 18%)

Common (1% to 10%): Vomiting, diarrhea

Frequency not reported: Constipation[Ref]

Some side effects associated with this drug treatment in fascioliasis (e.g., abdominal pain) could be secondary to the infection; such effects may be more severe and/or may occur more often in patients with heavy worm burden.[Ref]

Dermatologic

Very common (10% or more): Hyperhidrosis (up to 25%), urticaria (up to 11%)

Common (1% to 10%): Pruritus[Ref]

Metabolic

Very common (10% or more): Decreased appetite (up to 18%)[Ref]

Nervous system

Very common (10% or more): Headache (up to 14%)

Common (1% to 10%): Vertigo[Ref]

Hepatic

Posttreatment elevations in bilirubin, AST, and ALT were reported in 6.8%, 4.5%, and 3% of patients with normal liver enzyme values at baseline, respectively.

Some side effects associated with this drug treatment in fascioliasis (e.g., biliary colic, jaundice) could be secondary to the infection; such effects may be more severe and/or may occur more often in patients with heavy worm burden.

Common (1% to 10%): Elevated bilirubin, elevated AST, elevated ALT, jaundice (included jaundice, ocular icterus)

Frequency not reported: Biliary colic, transient increases in liver enzymes, transient increases in total bilirubin

Respiratory

Common (1% to 10%): Dyspnea, cough[Ref]

Other

Posttreatment elevations in alkaline phosphatase were reported in 4.2% of patients with normal liver enzyme values at baseline.

Resistance to this drug has been reported outside the US.[Ref]

Common (1% to 10%): Elevated alkaline phosphatase, asthenia, chest pain, pyrexia, chest discomfort

Postmarketing reports: Drug resistance[Ref]

Musculoskeletal

Common (1% to 10%): Musculoskeletal chest pain

Frequency not reported: Arthralgia, back pain, spinal pain[Ref]

Genitourinary

Frequency not reported: Chromaturia[Ref]

References

1. "Product Information. Egaten (triclabendazole)." Novartis Pharmaceuticals, East Hanover, NJ.

More about triclabendazole

Consumer resources

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Egaten

Professional resources

Related treatment guides

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.