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Tisseel Side Effects

Generic name: fibrin sealant topical

Medically reviewed by Drugs.com. Last updated on Dec 22, 2023.

Note: This document contains side effect information about fibrin sealant topical. Some dosage forms listed on this page may not apply to the brand name Tisseel.

Applies to fibrin sealant topical: solution. Other dosage forms:

Serious side effects of Tisseel

Along with its needed effects, fibrin sealant topical (the active ingredient contained in Tisseel) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking fibrin sealant topical:

Less common

Incidence not known

Other side effects of Tisseel

Some side effects of fibrin sealant topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to fibrin sealant topical: topical kit, topical solution.

General

General side effects have been reported including rare reports of serious adverse events such as paralysis and other compressive complications possibly related to the use of fibrin sealant in combination with resorbable hemostatic agents. There have also been rare reports of fatalities following the misadministration of topical thrombin.[Ref]

Hypersensitivity

Hypersensitivity side effects such as anaphylactic and anaphylactoid reactions including shock have been reported rarely.[Ref]

Cardiovascular

Cardiovascular side effects including tachycardia, bradycardia, hypotension, and thromboembolic complications have been reported rarely.[Ref]

Respiratory

Respiratory side effects including severe dyspnea have been reported rarely.[Ref]

Dermatologic

Dermatologic side effects including flush, urticaria, and pruritus have been reported rarely.[Ref]

Gastrointestinal

Gastrointestinal side effects including nausea have been reported rarely.

Other

Other side effects including increased D-dimer levels have been reported in a clinical study on cardiovascular surgery, but did not exceed values reported in the literature occurring after this type of surgery.[Ref]

A D-dimer is a fragment produced during the degradation of a clot. Postoperatively increased D-dimers may result at least partly from the degradation of fibrin sealant.[Ref]

References

1. (2008) "Product Information. Tisseel (fibrin sealant topical)." Baxter Healthcare Corporation

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.