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Tisseel Side Effects

Generic Name: fibrin sealant topical

Note: This page contains side effects data for the generic drug fibrin sealant topical. It is possible that some of the dosage forms included below may not apply to the brand name Tisseel.

For the Consumer

Applies to fibrin sealant topical: solution

As well as its needed effects, fibrin sealant topical (the active ingredient contained in Tisseel) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking fibrin sealant topical, check with your doctor or nurse immediately:

Less common:
  • Collection of blood or fluids under the skin
  • deep, dark purple bruise
  • itching, pain, redness, or swelling of the skin, wound, or treated area
Incidence not known:
  • Blurred vision
  • chest pain, discomfort, or tightness
  • confusion
  • cough
  • difficulty breathing
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, slow, pounding, or irregular heartbeat or pulse
  • flushing, redness of the skin
  • hives, itching, skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness, dizziness, or fainting
  • numbness or tingling in the face, arms, or legs
  • pain in the chest, groin, or legs, especially the calves
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • severe, sudden headache
  • shortness of breath
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sweating
  • trouble healing
  • trouble speaking or walking
  • unusual tiredness or weakness
  • unusually warm skin

Minor Side Effects

Some fibrin sealant topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • nausea

For Healthcare Professionals

Applies to fibrin sealant topical: topical kit, topical solution

General

General side effects have been reported including rare reports of serious adverse events such as paralysis and other compressive complications possibly related to the use of fibrin sealant in combination with resorbable hemostatic agents. There have also been rare reports of fatalities following the misadministration of topical thrombin.[Ref]

Hypersensitivity

Hypersensitivity side effects such as anaphylactic and anaphylactoid reactions including shock have been reported rarely.[Ref]

Cardiovascular

Cardiovascular side effects including tachycardia, bradycardia, hypotension, and thromboembolic complications have been reported rarely.[Ref]

Respiratory

Respiratory side effects including severe dyspnea have been reported rarely.[Ref]

Dermatologic

Dermatologic side effects including flush, urticaria, and pruritus have been reported rarely.[Ref]

Gastrointestinal

Gastrointestinal side effects including nausea have been reported rarely.

Other

A D-dimer is a fragment produced during the degradation of a clot. Postoperatively increased D-dimers may result at least partly from the degradation of fibrin sealant.[Ref]

Other side effects including increased D-dimer levels have been reported in a clinical study on cardiovascular surgery, but did not exceed values reported in the literature occurring after this type of surgery.[Ref]

References

1. "Product Information. Tisseel (fibrin sealant topical)." Baxter Healthcare Corporation, Deerfield, IL.

It is possible that some side effects of Tisseel may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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