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Tisseel Duploject Kit

Generic name: fibrin sealant topical (FYE brin SEE lant TOP i kal)
Brand name: Artiss, Artiss Duo Set, Artiss Duploject, Tisseel, Tisseel Duploject Kit, Tisseel Valupak Kit
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by on Jan 25, 2021. Written by Cerner Multum.

What is Tisseel Duploject Kit?

Fibrin sealant is made of two substances from human plasma that work together to help your blood clot.

Tisseel Duploject Kit is used to help control bleeding during surgery when other ways to close a wound or incision (such as stitches, bands, or heat) cannot be used. This medicine may also be used to prevent leaks from a wound left in stomach tissue after a colostomy is removed.

Tisseel Duploject Kit is sometimes used to help skin tissues stick together during skin graft procedures or cosmetic surgery.

Tisseel Duploject Kit may also be used for purposes not listed in this medication guide.


You should not be treated with Tisseel Duploject Kit if you are allergic to cows or products made from cows.

Before taking this medicine

You should not be treated with Tisseel Duploject Kit if you are allergic to cows or products made from cows.

It is not known whether Tisseel Duploject Kit will harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether fibrin sealant topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use Tisseel Duploject Kit?

Tisseel Duploject Kit can be sprayed or dripped onto the affected skin or surgical area. Tisseel Duploject Kit is applied by a healthcare professional in a surgical or clinical setting.

Tisseel Duploject Kit is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

Some people develop symptoms of a viral infection after being treated with Tisseel Duploject Kit. Call your doctor if you have flu-like symptoms such as fever, chills, drowsiness, or a runny nose. You may also have joint pain and a skin rash about 2 weeks after the start of your flu symptoms.

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What happens if I miss a dose?

Because you will receive Tisseel Duploject Kit in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since Tisseel Duploject Kit is applied by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after being treated with Tisseel Duploject Kit?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Tisseel Duploject Kit side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching, warmth, redness, numbness, tingly feeling; nausea, vomiting, feeling light-headed, fast or slow heartbeats; wheezing, chest tightness, trouble breathing; swelling of your face, lips, tongue, or throat.

Fibrin sealant is sometimes applied with a spray device that uses gas pressure. High pressure may cause the release of air or gas under the skin tissues, where it can then travel throughout the body. This may be more likely when high pressure settings are improperly used by a healthcare provider during the spray application of fibrin sealant. Air or gas trapped within the body can cause serious or life-threatening effects. Talk with your doctor about this risk.

Tell your caregivers at once if you have:

  • chest pain, cough, trouble breathing, gasping for breath;

  • confusion, agitation, panic, extreme fear;

  • sudden numbness or weakness (especially on one side of the body);

  • sudden severe headache, slurred speech, problems with vision or balance;

  • blue-colored appearance of your skin or lips;

  • nausea, dizziness or spinning sensation;

  • a light-headed feeling, like you might pass out; or

  • redness, itching, irritation, or slow healing of the skin wound or treated area;

Common side effects may include:

  • itching; or

  • swelling or bruising.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Tisseel Duploject Kit?

It is not likely that other drugs you take orally or inject will have an effect on topically applied fibrin sealant. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.