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Generic Name: anagrelide (an AH gre lide)
Brand Name: Agrylin

Medically reviewed by on Oct 8, 2018 – Written by Cerner Multum

What is Agrylin?

Agrylin lowers platelets (blood-clotting cells) in the body, which helps prevent blood clots from forming.

Agrylin is used to treat a blood cell disorder called thrombocythemia (also called thrombocytosis), which occurs when your body produces too many platelet cells.

Agrylin may also be used for purposes not listed in this medication guide.

Important Information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Agrylin if you are allergic to it.

To make sure Agrylin is safe for you, tell your doctor if you have:

It is not known whether Agrylin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether anagrelide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using anagrelide.

How should I take Agrylin?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG) before you take this medicine.

While using Agrylin, you may need frequent blood tests. Your heart, liver, and kidney function may also need to be checked.

If you need surgery, tell the surgeon ahead of time that you are using Agrylin.

You should not stop using Agrylin suddenly. Stopping suddenly may make your condition worse.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Agrylin?

Do not take aspirin unless your doctor has told you to. Follow your doctor's instructions about how much aspirin to take, and how often to take it.

Ask a doctor or pharmacist before using any pain, cold, allergy, or sleep medication. Aspirin (sometimes abbreviated as ASA) is contained in many combination medicines. Check the label to see if a medicine contains aspirin or ASA.

Ask your doctor before using Agrylin if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with this medicine may cause you to bruise or bleed easily.

Agrylin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats, fluttering in your chest;

  • sudden breathing problems, wheezing, dry cough or hack;

  • shortness of breath with mild exertion, swelling, rapid weight gain;

  • easy bruising or bleeding (nosebleeds, bleeding gums);

  • chest pain spreading to your jaw or shoulder, with sweating or general ill feeling;

  • sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; or

  • severe pain in your upper stomach spreading to your back, with nausea or vomiting.

Common side effects may include:

  • headache, weakness, dizziness;

  • flushing (warmth, redness, or tingly feeling);

  • stomach pain, gas, indigestion, loss of appetite;

  • nausea, vomiting, diarrhea;

  • swelling in your hands or feet;

  • fever, cough;

  • back pain; or

  • rash, itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Agrylin?

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with anagrelide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.