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Tetanus-Diphtheria Toxoids, Adult Side Effects

Generic name: diphtheria toxoid/tetanus toxoid

Medically reviewed by Last updated on Jan 25, 2024.

Note: This document contains side effect information about diphtheria toxoid/tetanus toxoid. Some dosage forms listed on this page may not apply to the brand name Tetanus-Diphtheria Toxoids, Adult.

Applies to diphtheria toxoid/tetanus toxoid: intramuscular suspension.

Serious side effects

Along with its needed effects, diphtheria toxoid/tetanus toxoid may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking diphtheria toxoid/tetanus toxoid:

Less common

Incidence not known

Other side effects

Some side effects of diphtheria toxoid/tetanus toxoid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Incidence not known

For Healthcare Professionals

Applies to diphtheria toxoid/tetanus toxoid: intramuscular suspension.


The most common adverse events were slight pain at the injection site, crying, fever, and loss of appetite.[Ref]


Very common (10% or more): Crying (15.2%)

Common (1% to 10%): Fever 38C or higher[Ref]


Very common (10% or more): Slight pain at the injection site (11%)

Uncommon (0.1% to 1%): Redness/swelling 2.5 cm or larger at the injection site, moderate pain at the injection site, hardness 2.5 cm or larger at the injection site

Postmarketing reports: Injection site inflammation, injection site hypersensitivity[Ref]


Common (1% to 10%): Loss of appetite[Ref]

Nervous system

Frequency not reported: Dizziness

Postmarketing reports: Convulsion, somnolence, syncope, headache[Ref]


Postmarketing reports: Lymphadenopathy[Ref]


Postmarketing reports: Pallor[Ref]


Postmarketing reports: Rash, urticaria[Ref]


Postmarketing reports: Nausea[Ref]

More about Tetanus-Diphtheria Toxoids, Adult (diphtheria toxoid / tetanus toxoid)

Patient resources

Other brands

TDVAX, Decavac (Td)

Professional resources

Other brands


Related treatment guides


1. Product Information. Tetanus-Diphtheria Toxoids, Adult (Td) (tetanus-diphth toxoids (Td) adult/adol). sanofi pasteur. 2022.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.