Skip to Content

Tenivac (Td) Side Effects

Generic Name: diphtheria toxoid / tetanus toxoid

Note: This page contains side effects data for the generic drug diphtheria toxoid / tetanus toxoid. It is possible that some of the dosage forms included below may not apply to the brand name Tenivac (Td).

For the Consumer

Applies to diphtheria toxoid / tetanus toxoid: intramuscular suspension

As well as its needed effects, diphtheria toxoid / tetanus toxoid may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking diphtheria toxoid / tetanus toxoid, check with your doctor or nurse immediately:

Less common:
  • Fever
  • general feeling of discomfort or illness
  • unusual tiredness or weakness
Incidence not known:
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chills
  • convulsions
  • cough
  • difficulty with swallowing
  • dizziness
  • fainting
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • shortness of breath
  • skin rash
  • swelling or puffiness of the face
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • tightness in the chest
  • tingling of the hands or feet
  • unusual weight gain or loss
  • wheezing

Minor Side Effects

Some diphtheria toxoid / tetanus toxoid side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Hard lumps, redness, tenderness, or warmth at the injection site
Less common:
  • Headache
Incidence not known:
  • Difficulty with moving
  • joint pain
  • lack or loss of strength
  • muscle aching or cramping
  • muscle stiffness
  • nausea
  • pain in the arms or legs
  • swollen joints
  • vomiting

For Healthcare Professionals

Applies to diphtheria toxoid / tetanus toxoid: intramuscular suspension


Local side effects have included erythema, tenderness, induration, swelling, redness, warmth, cellulitis, and nodules at the injection site.[Ref]


Hypersensitivity side effects have included allergic reactions (such as rash, urticaria, pruritus, and face edema) and anaphylactoid reactions.[Ref]


General side effects have included malaise and temperature elevations, pyrexia, chills, pain, asthenia, fatigue, and peripheral edema.[Ref]

Nervous system

Nervous system side effects have included headache, paresthesia, dizziness, syncope, and convulsions.[Ref]


Gastrointestinal side effects have included nausea and vomiting.[Ref]


Musculoskeletal side effects have included myalgia, arthralgia, pain in extremities, and musculoskeletal stiffness.[Ref]


1. "Product Information. Decavac (tetanus-diphtheria toxoids)." Aventis Pasteur Inc, Swiftwater, PA.

It is possible that some side effects of Tenivac (Td) may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.