Tarlatamab Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 10, 2024.

Applies to tarlatamab: intravenous powder for injection.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;

• signs of infection--fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding; or

• symptoms of liver failure--diarrhea, loss of appetite, pain or swelling in your stomach, swelling in your legs, easy bleeding, drowsiness, confusion, or jaundice (yellowing of the skin or eyes).

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• abnormal lab results;

• constipation, nausea;

• metallic taste in your mouth;

• muscle or bone pain;

• tiredness;

• fever; or

• loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For healthcare professionals

Applies to tarlatamab: intravenous powder for injection.

General adverse events

The most common adverse events were cytokine release syndrome, fatigue, pyrexia, dysgeusia, decreased appetite and musculoskeletal pain.^[Ref]

Immunologic

• Very common (10% or more): Cytokine release syndrome (55%)^[Ref]

Musculoskeletal

• Very common (10% or more): Musculoskeletal pain (30%)^[Ref]

Metabolic

• Very common (10% or more): Hyponatremia (68%), decreased potassium (50%), decreased magnesium (33%), increased sodium (26%)^[Ref]

Genitourinary

• Very common (10% or more): Urinary tract infection (10%)^[Ref]

Hepatic

• Very common (10% or more): Increased hepatic enzymes: AST (44%), ALT (42%)

Respiratory

• Very common (10% or more): Dyspnea (17%), cough (17%)
• Common (1% to 10%): Pneumonia

Other

• Very common (10% or more): Fatigue (51%), pyrexia (36%), decrease appetite (34%)^[Ref]

Hematologic

• Very common (10% or more): Anemia (27%), decreased lymphocytes all grades (84%), decreased hemoglobin (58%), decreased white blood cells (44%), decreased platelets (33%), decreased neutrophils (12%)^[Ref]

Nervous system

• Very common (10% or more): Dysgeusia (36%)^[Ref]

Renal

• Very common (10% or more): Increased creatinine (29%)

Gastrointestinal

• Very common (10% or more): Nausea (22%), constipation (30%)^[Ref]

See also:

Further information

Tarlatamab side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer