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Somatrogon Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 5, 2025.

Applies to somatrogon: subcutaneous solution.

Serious side effects of somatrogon

Along with its needed effects, somatrogon may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking somatrogon:

More common side effects

  • pale skin
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common side effects

  • constipation
  • depressed mood
  • dry skin and hair
  • feeling cold
  • hair loss
  • hoarseness or husky voice
  • muscle cramps and stiffness
  • slowed heartbeat
  • weight gain

Incidence not known

  • bloating
  • blurred vision
  • change in ability to see colors, especially blue or yellow
  • chest tightness
  • chills
  • cough
  • darkened urine
  • darkening of the skin
  • decrease amount in urine
  • diarrhea
  • difficulty swallowing
  • dizziness
  • dry mouth
  • fainting
  • fast heartbeat
  • flushed, dry skin
  • headache
  • hives, itching, skin rash
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • loss of consciousness
  • mental depression
  • nausea
  • noisy, rattling breathing
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • stomachache
  • sweating
  • swelling of the fingers, hands, feet, or lower legs
  • unexplained weight loss
  • vomiting
  • yellow eyes or skin

Other side effects of somatrogon

Some side effects of somatrogon may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • cough producing mucus
  • difficulty in moving
  • earache
  • joint pain
  • muscle pain
  • redness or swelling in the ear
  • sore throat
  • stuffy or runny nose

For healthcare professionals

Applies to somatrogon: subcutaneous solution.

General adverse events

Adverse reactions occurring in 5% of patients or greater included injection site reactions, nasopharyngitis, headache, pyrexia, anemia, cough, vomiting, hypothyroidism, abdominal pain, rash, and oropharyngeal pain.[Ref]

Dermatologic

Endocrine

Gastrointestinal

Hematologic

Hypersensitivity

Immunologic

Local

Metabolic

Musculoskeletal

Nervous system

Ocular

Oncologic

Other

Respiratory

References

1. (2023) "Product Information. Ngenla (somatrogon)." Pfizer U.S. Pharmaceuticals Group

Further information

Somatrogon side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.