Sodium Thiosulfate Side Effects

Medically reviewed by Drugs.com. Last updated on Dec 24, 2024.

Applies to sodium thiosulfate: intravenous solution.

Precautions

It is very important that your doctor check your or your child's progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Check with your doctor right away if you have chest pain, cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, or skin rash, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, trouble breathing, or unusual tiredness or weakness.

This medicine may increase sodium and decrease potassium in your blood. Check with your doctor right away if you have muscle weakness, seizures, or unusual tiredness or weakness.

Serious side effects of sodium thiosulfate

Along with its needed effects, sodium thiosulfate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking sodium thiosulfate:

Get emergency help immediately if any of the following symptoms of overdose occur while taking sodium thiosulfate:

Symptoms of overdose

• agitation
• blurred vision
• mental changes
• muscle cramps
• nausea and vomiting
• pain in the joints
• ringing in the ears
• seeing, hearing, or feeling things that are not there

Other side effects of sodium thiosulfate

Some side effects of sodium thiosulfate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to sodium thiosulfate: compounding powder, intravenous solution.

Gastrointestinal adverse events

• Frequency not reported: Nausea, vomiting, diarrhea, osmotic disturbances^[Ref]

Nervous system

• Frequency not reported: Headache, disorientation, salty taste in mouth, warm sensation over body^[Ref]

Cardiovascular

• Frequency not reported: Hypotension^[Ref]

Psychiatric

• Frequency not reported: Psychotic behavior including agitation, delusions, and hallucinations^[Ref]

Musculoskeletal

• Frequency not reported: Arthralgia, hyperreflexia, muscle cramps^[Ref]

Hematologic

• Frequency not reported: Prolonged bleeding time^[Ref]

Other

• Frequency not reported: Tinnitus^[Ref]

Ocular

• Frequency not reported: Blurred vision^[Ref]

Genitourinary

• Frequency not reported: Diuretic effects^[Ref]

See also:

Further information

Sodium thiosulfate side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer