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Sodium thiosulfate Side Effects

For the Consumer

Applies to sodium thiosulfate: intravenous solution

As well as its needed effects, sodium thiosulfate may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking sodium thiosulfate, check with your doctor immediately:

Symptoms of overdose:
  • Agitation
  • blurred vision
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • mental changes
  • muscle cramps
  • nausea and vomiting
  • pain in the joints
  • ringing in the ears

For Healthcare Professionals

Applies to sodium thiosulfate: compounding powder, intravenous solution


Frequency not reported: Nausea, vomiting, diarrhea, osmotic disturbances[Ref]

Nervous system

Frequency not reported: Headache, disorientation, salty taste in mouth, warm sensation over body[Ref]


Frequency not reported: Hypotension[Ref]


Frequency not reported: Psychotic behavior including agitation, delusions, and hallucinations[Ref]


Frequency not reported: Arthralgia, hyperreflexia, muscle cramps[Ref]


Frequency not reported: Prolonged bleeding time[Ref]


Frequency not reported: Tinnitus[Ref]


Frequency not reported: Blurred vision[Ref]


Frequency not reported: Diuretic effects[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Sodium Thiosulfate (sodium thiosulfate)." American Regent Laboratories Inc, Shirley, NY.

It is possible that some side effects of sodium thiosulfate may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.