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Sodium thiosulfate Side Effects

For the Consumer

Applies to sodium thiosulfate: intravenous solution

Along with its needed effects, sodium thiosulfate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sodium thiosulfate:

Symptoms of overdose
  • Agitation
  • blurred vision
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • mental changes
  • muscle cramps
  • nausea and vomiting
  • pain in the joints
  • ringing in the ears

For Healthcare Professionals

Applies to sodium thiosulfate: compounding powder, intravenous solution


Frequency not reported: Nausea, vomiting, diarrhea, osmotic disturbances[Ref]

Nervous system

Frequency not reported: Headache, disorientation, salty taste in mouth, warm sensation over body[Ref]


Frequency not reported: Hypotension[Ref]


Frequency not reported: Psychotic behavior including agitation, delusions, and hallucinations[Ref]


Frequency not reported: Arthralgia, hyperreflexia, muscle cramps[Ref]


Frequency not reported: Prolonged bleeding time[Ref]


Frequency not reported: Tinnitus[Ref]


Frequency not reported: Blurred vision[Ref]


Frequency not reported: Diuretic effects[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Sodium Thiosulfate (sodium thiosulfate)." American Regent Laboratories Inc, Shirley, NY.

Some side effects of sodium thiosulfate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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