Skip to Content

Serophene Side Effects

Generic Name: clomiphene

Note: This document contains side effect information about clomiphene. Some of the dosage forms listed on this page may not apply to the brand name Serophene.

For the Consumer

Applies to clomiphene: oral tablet

Along with its needed effects, clomiphene (the active ingredient contained in Serophene) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking clomiphene:

More common

Check with your doctor as soon as possible if any of the following side effects occur while taking clomiphene:

Less common or rare

  • Blurred vision
  • decreased or double vision or other vision problems
  • seeing flashes of light
  • sensitivity of eyes to light
  • yellow eyes or skin

Some side effects of clomiphene may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common or rare

For Healthcare Professionals

Applies to clomiphene: compounding powder, oral tablet

General

At recommended doses, this drug is well tolerated. Most side effects have been mild and transient and disappear promptly after treatment has stopped.[Ref]

Genitourinary

Very common (10% or more): Ovarian enlargement (up to 13.6%), vasomotor flushes (10.4%)
Common (1% to 10%): Abdominal/pelvic discomfort/distention/bloating, breast discomfort, uterine bleeding abnormal, intermenstrual spotting, menorrhagia
Frequency not reported: Urinary frequency increased, urinary volume increased, vaginal dryness
Postmarketing reports: Endometriosis, ovarian hemorrhage, tubal pregnancy, uterine hemorrhage, reduced endometrial thickness, ovarian hemorrhage, tubal pregnancy, uterine hemorrhage, endometrial thickness reduced

Fetal/Neonatal Patients:
-Postmarketing reports: Hypospadias, cloacal exstrophy[Ref]

Ocular

Common (1% to 10%): Blurred vision, lights, floaters, waves, unspecified visual complaints, photophobia, diplopia, scotomata, phosphenes
Postmarketing reports: Abnormal accommodation, cataract, eye pain, macular edema, optic neuritis, photopsia, posterior vitreous detachment, retinal hemorrhage, retinal thrombosis, retinal vascular spasm, temporary or prolonged loss of vision

Fetal/Neonatal Patients:
-Postmarketing reports: Eye malformed, lens malformed/cataract[Ref]

Cardiovascular

Postmarketing reports: Arrhythmia, chest pain, hypertension, palpitation, phlebitis, tachycardia, thrombophlebitis

Fetal/Neonatal Patients:
-Postmarketing reports: Septal heart defect, muscular ventricular septal defect, patent ductus arteriosus, tetralogy of Fallot, coarctation of aorta[Ref]

Endocrine

Postmarketing reports: Thyroid disorder

Fetal/Neonatal Patients:
-Postmarketing reports: Dwarfism[Ref]

Oncologic

Frequency not reported: Ovarian cancer, ovarian tumor
Postmarketing reports: Ovarian cyst, hepatic hemangiosarcoma, liver cell adenoma, hepatocellular carcinoma, fibrocystic disease, breast carcinoma, endometrial carcinoma, astrocytoma, pituitary tumor, prolactinoma, neurofibromatosis, glioblastoma multiforme, brain abscess, ovary (luteoma of pregnancy, dermoid cyst of the ovary, ovarian carcinoma, hydatiform mole, choriocarcinoma, melanoma, myeloma, perianal cysts, renal cell carcinoma, Hodgkin's lymphoma, tongue carcinoma, bladder carcinoma

Fetal/Neonatal Patients:
-Postmarketing reports: Neuroectodermal tumor, thyroid tumor, hepatoblastoma, lymphocytic leukemia[Ref]

Nervous system

Common (1% to 10%): Headache
Frequency not reported: Dizziness, lightheadedness
Postmarketing reports: Migraine headache, paresthesia, seizure, stroke, syncope

Fetal/Neonatal Patients:
-Postmarketing reports: Neural tube defect, anencephaly, meningomyelocele), microcephaly, hydrocephalus[Ref]

Dermatologic

Frequency not reported: Dermatitis, rash, hair loss/dry hair
Postmarketing reports: Acne, allergic reaction, erythema, erythema multiforme, erythema nodosum, hypertrichosis, pruritus, urticaria[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting
Frequency not reported: Acute abdomen, constipation, diarrhea
Postmarketing reports: Pancreatitis

Fetal/Neonatal Patients:
-Postmarketing reports: Cleft lip/palate, imperforate anus, tracheoesophageal fistula, diaphragmatic hernia, omphalocele[Ref]

Hematologic

Postmarketing reports: Leukocytosis[Ref]

Hepatic

Postmarketing reports: Increased transaminases, hepatitis[Ref]

Metabolic

Frequency not reported: Appetite increased, serum desmosterol levels increase
Postmarketing reports: Hypertriglyceridemia[Ref]

Musculoskeletal

Postmarketing reports: Arthralgia, back pain, myalgia

Fetal/Neonatal Patients:
-Postmarketing reports: Abnormal bone development, skeletal malformations of skull/face/nasal passages/jaw/hand limb/foot/spine/joints[Ref]

Other

Frequency not reported: Fatigue, vertigo, weight gain, weight loss
Postmarketing reports: Fever, tinnitus, weakness, edema

Fetal/Neonatal Patients:
-Postmarketing reports: Down's syndrome, ear abnormal, deafness[Ref]

Psychiatric

Frequency not reported: Depression, insomnia, nervous tension
Postmarketing reports: Anxiety, irritability, mood changed, psychosis

Fetal/Neonatal Patients:
-Postmarketing reports: Mental retardation[Ref]

Respiratory

Postmarketing reports: Pulmonary embolism, shortness of breath

Fetal/Neonatal Patients:
-Postmarketing reports: Lung tissue malformation[Ref]

Renal

Fetal/Neonatal Patients:
-Postmarketing reports: Renal agenesis, renal dysgenesis[Ref]

References

1. "Product Information. ClomiPHENE Citrate (clomiPHENE (clomiphene))." Teva Pharmaceuticals USA, North Wales, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Hide