Ryplazim Side Effects

Generic name: plasminogen, human

Medically reviewed by Drugs.com. Last updated on Apr 4, 2025.

Note: This document provides detailed information about Ryplazim.

Applies to plasminogen, human: intravenous powder for solution Side Effects associated with plasminogen, human. Some dosage forms listed on this page may not apply specifically to the brand name Ryplazim.

Applies to plasminogen, human: intravenous powder for solution.

Precautions

It is very important that your doctor check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.

Check with your doctor right away if you have any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, headache, dizziness, or weakness, pain, swelling, or discomfort in a joint, pinpoint red spots on your skin, unusual nosebleeds, or unusual vaginal bleeding that is heavier than normal. These may be symptoms of bleeding problems.

This medicine may cause tissue sloughing or shedding, which may cause breathing problems, stomach or bowel problems, or urinating problems. Check with your doctor right away if you have blood in the urine or stools, cough or hoarseness, lower back or side pain, sore throat, trouble breathing, or voice changes.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Check with your doctor right away if you have chest tightness, cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, skin rash, trouble breathing, or unusual tiredness or weakness.

This medicine is made from donated human blood. Some human blood products have transmitted certain viruses (eg, Creutzfeldt-Jacob disease) to people who have received them, although the risk is low. Human donors and donated blood are both tested for viruses to keep the transmission risk low. Talk with your doctor if you have concerns about this risk.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Ryplazim

Along with its needed effects, plasminogen, human (the active ingredient contained in Ryplazim) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking plasminogen, human:

Other side effects of Ryplazim

Some side effects of plasminogen, human may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to plasminogen, human: intravenous powder for injection.

General adverse events

The most frequent side effects in 10% or more patients were abdominal pain, bloating, nausea, fatigue, pain in the extremity, hemorrhage, constipation, dry mouth, headache, dizziness, arthralgia, and back pain.^[Ref]

Gastrointestinal

• Very common (10% or more): Abdominal pain (16%), gastric dilatation (16%), nausea (16%), constipation (11%), dry mouth (11%)^[Ref]

Hematologic

• Very common (10% or more): Hemorrhage (16%)^[Ref]

Musculoskeletal

• Very common (10% or more): Arthralgia (11%), back pain (11%), pain in extremity (16%)^[Ref]

Other

• Very common (10% or more): Fatigue (16%)^[Ref]

Nervous system

• Very common (10% or more): Headache (11%), dizziness (11%)^[Ref]

See also:

Further information

Ryplazim side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer