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Ryplazim Side Effects

Generic name: plasminogen, human

Medically reviewed by Last updated on Apr 29, 2023.

Note: This document contains side effect information about plasminogen, human. Some dosage forms listed on this page may not apply to the brand name Ryplazim.

Applies to plasminogen, human: intravenous powder for solution.

Serious side effects of Ryplazim

Along with its needed effects, plasminogen, human (the active ingredient contained in Ryplazim) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking plasminogen, human:

More common

  • Bleeding gums
  • bloating
  • constipation
  • coughing up blood
  • difficulty in breathing or swallowing
  • dizziness
  • headache
  • increased menstrual flow or vaginal bleeding
  • nausea
  • nosebleeds
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • stomach pain

Incidence not known

  • Chest pain or tightness
  • cough or hoarseness
  • fast heartbeat
  • hives, itching, skin rash
  • lower back or side pain
  • lower stomach pain
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • sore throat
  • unusual tiredness or weakness
  • voice changes
  • vomiting of blood or material that looks like coffee grounds

Other side effects of Ryplazim

Some side effects of plasminogen, human may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to plasminogen, human: intravenous powder for injection.


The most frequent side effects in 10% or more patients were abdominal pain, bloating, nausea, fatigue, pain in the extremity, hemorrhage, constipation, dry mouth, headache, dizziness, arthralgia, and back pain.[Ref]


Very common (10% or more): Abdominal pain (16%), gastric dilatation (16%), nausea (16%), constipation (11%), dry mouth (11%)[Ref]


Very common (10% or more): Hemorrhage (16%)[Ref]


Very common (10% or more): Arthralgia (11%), back pain (11%), pain in extremity (16%)[Ref]


Very common (10% or more): Fatigue (16%)[Ref]

Nervous system

Very common (10% or more): Headache (11%), dizziness (11%)[Ref]


1. Product Information. Ryplazim (plasminogen, human). Prometic Biotherapeutics Inc. 2022.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.