Ryplazim Side Effects

Generic name: plasminogen, human

Medically reviewed by Drugs.com. Last updated on Feb 5, 2024.

Note: This document contains side effect information about plasminogen, human. Some dosage forms listed on this page may not apply to the brand name Ryplazim.

Applies to plasminogen, human: intravenous powder for solution.

Serious side effects of Ryplazim

Along with its needed effects, plasminogen, human (the active ingredient contained in Ryplazim) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking plasminogen, human:

More common

Bleeding gums
bloating
constipation
coughing up blood
difficulty in breathing or swallowing
dizziness
headache
increased menstrual flow or vaginal bleeding
nausea
nosebleeds
paralysis
prolonged bleeding from cuts
red or black, tarry stools
red or dark brown urine
stomach pain

Incidence not known

Chest pain or tightness
cough or hoarseness
fast heartbeat
hives, itching, skin rash
lower back or side pain
lower stomach pain
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
sore throat
unusual tiredness or weakness
voice changes
vomiting of blood or material that looks like coffee grounds

Other side effects of Ryplazim

Some side effects of plasminogen, human may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back, arm, or leg pain
difficulty in moving
dry mouth
muscle pain or stiffness
pain in the joints

For Healthcare Professionals

Applies to plasminogen, human: intravenous powder for injection.

General

The most frequent side effects in 10% or more patients were abdominal pain, bloating, nausea, fatigue, pain in the extremity, hemorrhage, constipation, dry mouth, headache, dizziness, arthralgia, and back pain.^[Ref]