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Rifapentine Side Effects

Medically reviewed by Last updated on Jan 22, 2024.

Applies to rifapentine: oral tablet.

Serious side effects of Rifapentine

Along with its needed effects, rifapentine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rifapentine:

More common

Less common


Incidence not known

Other side effects of Rifapentine

Some side effects of rifapentine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common


For Healthcare Professionals

Applies to rifapentine: oral tablet.


The most common side effects with the regimen for active pulmonary tuberculosis included anemia, lymphopenia, hemoptysis, neutropenia, cough, thrombocytosis, increased sweating, increased ALT, increased AST, back pain, rash, anorexia, arthralgia, increased blood urea, and headache. The most common side effect with the regimen for latent tuberculosis infection was hypersensitivity reaction.[Ref]


Frequency not reported: Tachycardia, palpitation, orthostatic hypotension, pericarditis, hematoma, thrombosis, flushing, hypotension[Ref]


Common (1% to 10%): Increased sweating/hyperhidrosis, rash, pruritus/itching, maculopapular rash

Uncommon (0.1% to 1%): Skin reaction

Frequency not reported: Purpura, urticaria, skin discoloration, angioedema

Postmarketing reports: Severe cutaneous adverse reactions (e.g., Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms [DRESS] syndrome)[Ref]


Common (1% to 10%): Nausea, dyspepsia, vomiting, diarrhea, abdominal pain

Frequency not reported: Clostridioides difficile-associated diarrhea, gastritis, esophagitis, pancreatitis, salivary gland enlargement, constipation, dry mouth, esophageal irritation[Ref]


Frequency not reported: Hematuria, vaginitis, vaginal hemorrhage, leukorrhea, vulvovaginal candidiasis, vulvovaginal pruritus[Ref]


Very common (10% or more): Anemia (up to 11.4%), lymphopenia (up to 10.5%)

Common (1% to 10%): Neutropenia, thrombocytosis, leukocytosis, thrombocytopenia, lymphadenopathy

Frequency not reported: Leukopenia, lymphocytosis[Ref]


Common (1% to 10%): Increased ALT, increased AST, hepatotoxicity

Uncommon (0.1% to 1%): Hepatitis

Frequency not reported: Bilirubinemia, hepatomegaly, jaundice[Ref]


Common (1% to 10%): Hypersensitivity/hypersensitivity reaction (including hypotension, urticaria, angioedema, acute bronchospasm, conjunctivitis; OR weakness, fatigue, nausea, vomiting, headache, fever, aches, sweats, dizziness, shortness of breath, flushing, chills)

Frequency not reported: Anaphylaxis[Ref]


Common (1% to 10%): Anorexia

Frequency not reported: Hyperglycemia, hyperuricemia, gout, hyperkalemia, decreased appetite, hyperlipidemia[Ref]


Common (1% to 10%): Back pain, arthralgia

Frequency not reported: Arthritis, myalgia/muscle pain, myositis, rhabdomyolysis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Frequency not reported: Somnolence, convulsion, paresthesia, peripheral neuropathy, syncope[Ref]


Common (1% to 10%): Conjunctivitis[Ref]


Common (1% to 10%): Fever/pyrexia

Frequency not reported: Increased alkaline phosphatase, asthenia, facial edema, fungal infection, abortion, death, fatigue, chest pain, chills, feeling jittery, viral infection, aches, body fluid discoloration, weakness, influenza-like syndrome


Frequency not reported: Anxiety, confusion, depression, disorientation, suicidal ideation[Ref]


Common (1% to 10%): Increased blood urea

Frequency not reported: Azotemia[Ref]


Common (1% to 10%): Hemoptysis, coughing/cough

Frequency not reported: Dysphonia, dyspnea/shortness of breath, pneumonitis, pulmonary fibrosis, asthma, bronchospasm, laryngeal edema, laryngitis, pharyngitis, oropharyngeal pain, bronchial hyperactivity, epistaxis, acute bronchospasm[Ref]


1. Product Information. Priftin (rifapentine). sanofi-aventis. 2020;SUPPL-18.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.