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Rifapentine Side Effects

Medically reviewed by Last updated on Jan 24, 2022.


More frequently reported side effects include: diarrhea. Continue reading for a comprehensive list of adverse effects.

Applies to rifapentine: oral tablets.

Side effects include:

Neutropenia, increased AST/ALT, pyuria.

For Healthcare Professionals

Applies to rifapentine: oral tablet.


The most commonly reported side effects included anemia, lymphopenia, hemoptysis, and neutropenia.[Ref]


Very common (10% or more): Anemia (up to 11.4%), lymphopenia (up to 10.5%)

Common (1% to 10%): Leukocytosis, lymphadenopathy, neutropenia, thrombocytopenia, thrombocytosis

Frequency not reported: Leukopenia, lymphocytosis[Ref]


Common (1% to 10%): Abdominal pain, diarrhea, dyspepsia, nausea, vomiting

Frequency not reported: Clostridium difficile-associated diarrhea, constipation, dry mouth, esophageal irritation, esophagitis, gastritis, pancreatitis, salivary gland enlargement[Ref]


Common (1% to 10%): Maculopapular rash, pruritus, rash, sweating increased

Uncommon (0.1% to 1%): Skin reaction

Frequency not reported: Facial edema, hyperhidrosis, itching, purpura, skin discoloration, sweats, urticaria[Ref]


Common (1% to 10%): ALT increased, AST increased, hepatotoxicity

Uncommon (0.1% to 1%): Hepatitis

Frequency not reported: Alkaline phosphatase increased, bilirubinemia, hepatomegaly, jaundice[Ref]


Common (1% to 10%): Coughing/cough, hemoptysis

Frequency not reported: Acute bronchospasm, asthma, bronchial hyperactivity, bronchospasm, dysphonia, dyspnea, epistaxis, laryngeal edema, laryngitis, oropharyngeal pain, pharyngitis, pneumonitis, pulmonary fibrosis, shortness of breath[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache

Frequency not reported: Convulsion, paresthesia, peripheral neuropathy, somnolence, syncope[Ref]


Common (1% to 10%): Arthralgia, back pain

Frequency not reported: Arthritis, muscle pain, myalgia, myositis, rhabdomyolysis[Ref]


Common (1% to 10%): Hypersensitivity/hypersensitivity reaction

Frequency not reported: Anaphylaxis, angioedema[Ref]


Common (1% to 10%): Fever

Frequency not reported: Abortion, aches, asthenia, body fluid discoloration, chills, death, fatigue, feeling jittery, pyrexia, weakness[Ref]


Common (1% to 10%): Anorexia

Frequency not reported: Decreased appetite, gout, hyperglycemia, hyperkalemia, hyperlipidemia, hyperuricemia, porphyria[Ref]


Common (1% to 10%): Nonprotein nitrogen increased

Frequency not reported: Azotemia, blood urea nitrogen (BUN) increased[Ref]


Common (1% to 10%): Conjunctivitis[Ref]


Frequency not reported: Chest pain, flushing, hematoma, hypotension, orthostatic hypotension, palpitation, pericarditis, tachycardia, thrombosis[Ref]


Frequency not reported: Anxiety, confusion, depression, disorientation, suicidal ideation[Ref]


Frequency not reported: Hematuria, leukorrhea, vaginal hemorrhage, vaginitis, vulvovaginal candidiasis, vulvovaginal pruritus[Ref]


Frequency not reported: Flu-like syndrome, fungal infection, viral infection[Ref]


1. "Product Information. Priftin (rifapentine)." Hoechst Marion Roussel (2001):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.