RhoGAM Side Effects
Generic Name: rho (d) immune globulin
Note: This page contains side effects data for the generic drug rho (d) immune globulin. It is possible that some of the dosage forms included below may not apply to the brand name RhoGAM.
For the Consumer
Applies to rho (d) immune globulin: injectable, powder for solution, solution
As well as its needed effects, rho (d) immune globulin (the active ingredient contained in RhoGAM) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking rho (d) immune globulin, check with your doctor or nurse immediately:Rare:
- Bloody urine
- decreased frequency of urination or amount of urine
- increased blood pressure
- increased thirst
- loss of appetite
- lower back pain
- nausea or vomiting
- pale skin
- swelling of the face, fingers, or lower legs
- troubled breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
- weight gain
Some rho (d) immune globulin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:Less common:
- Soreness at the place of injection
For Healthcare Professionals
Applies to rho (d) immune globulin: injectable powder for injection, injectable solution, intramuscular powder for injection, intramuscular solution
Very common (10% or more): Chills (34.7%), pyrexia/increased body temperature (32.6%)
Uncommon (0.1% to 1%): Malaise
Very rare (less than 0.01%): Death
Frequency not reported: Shivering, weakness
Postmarketing reports: Chest pain, fatigue, edema[Ref]
Hemolytic reaction includes hypotension, nausea, chills, headache, and a decrease in haptoglobin and hemoglobin.[Ref]
Very rare (less than 0.01%): Disseminated intravascular coagulation
Frequency not reported: Intravascular hemolysis, hemolysis resulting in death, clinically compromising anemia, extravascular hemolysis, hemolytic reaction
Postmarketing reports: Hemoglobinemia, disseminated intravascular coagulation[Ref]
Uncommon (0.1% to 1%): Injection site swelling, injection site pain
Rare (less than 0.1%): Injection site erythema, injection site induration, injection site warmth, injection site pruritus, injection site rash[Ref]
Very common (10% or more): Headache (14.3%)
Uncommon (0.1% to 1%): Dizziness, vertigo[Ref]
Uncommon (0.1% to 1%): Nausea, vomiting
Rare (less than 0.1%): Diarrhea[Ref]
Rare (less than 0.1%): Tachycardia, hypotension
Frequency not reported: Increase in blood pressure
Postmarketing reports: Cardiac arrest, cardiac failure, myocardial infarction[Ref]
Uncommon (0.1% to 1%): Skin reaction, erythema, pruritus, pallor, rash
Postmarketing reports: Hyperhidrosis[Ref]
Rare (less than 0.1%): Arthralgia, back pain
Postmarketing reports: Myalgia, muscle spasm, pain in extremities[Ref]
Very common (10% or more): Increase in blood bilirubin (21.4%)
Postmarketing reports: Jaundice[Ref]
Rare (less than 0.1%): Hypersensitivity, anaphylactic shock, anaphylactic reaction[Ref]
The most common adverse events were chills, pyrexia, increased bilirubin, and headache.[Ref]
Rare (less than 0.1%): Dyspnea
Postmarketing reports: Acute respiratory distress syndrome, transfusion related acute lung injury[Ref]
Frequency not reported: Acute renal insufficiency
Postmarketing reports: Renal failure, renal impairment[Ref]
Uncommon (0.1% to 1%): Transient positive anti-C antibody test
Frequency not reported: Sensitization to repeated injections of human globulin[Ref]
Postmarketing reports: Hemoglobinuria, anuria, chromaturia, hematuria[Ref]
1. "Product Information. RhoGAM Ultra-Filtered Plus (RHo (D) immune globulin)." Kedrion Biopharma Inc, Cambridge, MA.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
4. "Product Information. WinRho SDF (RHo (D) immune globulin)." Nabi, Boca Raton, FL.
5. "Product Information. Rhophylac (RHo (D) immune globulin)." ZLB Bioplasma Inc, Glendale, CA.
6. "Product Information. HyperRHO S/D Full Dose (RHo (D) immune globulin)." Talecris Biotherapeutics, Research Triangle Park, NC.
7. "Product Information. BayRHo-D (RHo (D) immune globulin)." Bayer, West Haven, CT.
It is possible that some side effects of RhoGAM may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
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